Genetic variant rs16944 in IL1B gene is a risk factor for early-onset sepsis susceptibility and outcome in preterm infants.
Early-onset sepsis (EOS)
IL1B gene
Preterm neonates
Single-nucleotide polymorphism (SNP)
Journal
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
ISSN: 1420-908X
Titre abrégé: Inflamm Res
Pays: Switzerland
ID NLM: 9508160
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
12
08
2019
accepted:
28
11
2019
revised:
25
11
2019
pubmed:
22
12
2019
medline:
21
11
2020
entrez:
22
12
2019
Statut:
ppublish
Résumé
Interleukin-1-B (IL1B) is a proinflammatory cytokine that plays an important role in sepsis. The aim of this study was to evaluate the relationships between IL1B-511G/A polymorphism and susceptibility and outcome of early-onset sepsis (EOS) in preterm infants. DNA was extracted from the buccal swabs of 471 (285 with EOS and 186 control) preterm infants. Genotypes of rs16944 polymorphism were determined with real-time PCR method. We found statistically significant higher frequency of IL1B-511AA genotype in EOS group than in control group (p = 0.012). Also, IL1B-511AA genotype is statistically significantly more frequent in patients with lethal EOS outcome (p = 0.011). Genotype IL1B-511AA was associated with susceptibility to EOS and it is a significant predictor of lethal outcome in preterm infants with EOS.
Identifiants
pubmed: 31863173
doi: 10.1007/s00011-019-01301-4
pii: 10.1007/s00011-019-01301-4
doi:
Substances chimiques
IL1B protein, human
0
Interleukin-1beta
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
155-157Subventions
Organisme : Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
ID : 175091
Références
Shane AL, Sánchez PJ, Stoll BJ. Neonatal sepsis. Lancet. 2017;390:1770–80.
doi: 10.1016/S0140-6736(17)31002-4
Rønnestad A, Abrahamsen TG, Medbø S, Reigstad H, Lossius K, Kaaresen PI, Engelund IE, Irgens LM, Markestad T. Septicemia in the first week of life in a Norwegian cohort of extremely premature infants. Pediatrics. 2005;115:262–8.
doi: 10.1542/peds.2004-1834
Mukhopadhyay S, Puopolo K. Risk assessment in neonatal early-onset sepsis. Semin Perinatol. 2012;36:408–15.
doi: 10.1053/j.semperi.2012.06.002
Kurt AN, Aygun AD, Godekmerdan A, Kurt A, Dogan Y, Yilmaz E. Serum IL-1beta, IL-6, IL-8, and TNF-alpha levels in early diagnosis and management of neonatal sepsis. Med Inflamm. 2007;31:397–402.
Chen H, Wilkins LM, Aziz N, Cannings C, Wyllie DH, Bingle C, Rogus J, Beck JD, Offenbacher S, Cork MJ, Rafie-Kolpin M, Hsieh CM, Kornman KS, Duff GW. Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context. Hum Mol Genet. 2006;15:519–29.
doi: 10.1093/hmg/ddi469
Varljen T, Rakic O, Sekulovic G, Jekic B, Maksimovic N, Rankovic Janevski M, Novakovic I, Damnjanovic T. Association between tumor necrosis factor-α promoter − 308 G/A polymorphism and early onset sepsis in preterm infants. Tohoku J Exp Med. 2019;247:259–64.
doi: 10.1620/tjem.247.259
Carvalho JK, Moore DB, Luz RA, Xavier-Elsas PP, Gaspar-Elsas MIC. Prediction of sepsis-related outcomes in neonates through systematic genotyping of polymorphisms in genes for innate immunity and inflammation: a narrative review and critical perspective. Sao Paulo Med J. 2013;131:338–50.
doi: 10.1590/1516-3180.2013.1315519
Treszl A, Kocsis I, Szathmári M, Schuler Á, Héninger E, Tulassay T, Vásárhelyi B. Genetic Variants of TNF-α, IL-1ß, IL-4 receptor α -chain, IL-6 and IL-10 genes are not risk factors for sepsis in low-birth-weight infants. Biol Neonate. 2003;83:241–5.
doi: 10.1159/000069484
Khaertynov KS, Anokhin VA, Rizvanov AA, Daviduk YN, Lubin SA. Genetic polymorphisms and bacterial infections in neonates. Bio Nano Sci. 2017;7:78–84.
Zhang A, Pan W, Gao J, Yue C, Zeng L, Gu W, Jiang J. Associations between interleukin-1 gene polymorphisms and sepsis risk: a meta-analysis. BMC Med Genet. 2014;15:8.
doi: 10.1186/1471-2350-15-8
Jiménez-Sousa MA, Medrano LM, Liu P, Almansa R, Fernández-Rodríguez A, Gómez-Sánchez E, Rico L, Heredia-Rodríguez M, Gómez-Pesquera E, Tamayo E, Resino S. IL-1B rs16944 polymorphism is related to septic shock and death. Eur J Clin Invest. 2017;47:53–62.
doi: 10.1111/eci.12702