Factors predicting in-hospital mortality among patients admitted with community acquired pneumonia at a tertiary care hospital Karachi, Pakistan.
Aged
Aged, 80 and over
Community-Acquired Infections
/ microbiology
Female
Hospital Mortality
Hospitalization
Humans
Male
Middle Aged
Pakistan
Pneumonia
/ microbiology
Retrospective Studies
Risk Factors
Staphylococcus aureus
Streptococcus pneumoniae
Survival Rate
Tertiary Care Centers
Tertiary Healthcare
community acquired pneumonia
mortality
outcomes
predictor
Journal
The clinical respiratory journal
ISSN: 1752-699X
Titre abrégé: Clin Respir J
Pays: England
ID NLM: 101315570
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
06
12
2018
revised:
13
03
2019
accepted:
04
12
2019
pubmed:
22
12
2019
medline:
28
1
2021
entrez:
22
12
2019
Statut:
ppublish
Résumé
Community Acquired Pneumonia (CAP) is associated with significant morbidity and mortality globally, but unfortunately there is limited data available from South East Asia. To determine the risk factors associated with in-hospital mortality in patients with CAP in a tertiary care hospital of Pakistan. A retrospective study was conducted on adult patients admitted with a diagnosis of CAP from January 2011 till December 2016. Their clinical records were reviewed and a multivariable analysis was done to determine the factors associated with in-hospital mortality. A total of 1100 files were reviewed, of which 509 were included in the analysis. The mean age was 63.6 ± 16.5 years and 302 (52.16%) were males. The most Common isolated pathogen was Staphylococcus aureus (23%). Overall mortality was 10.8%. On univariate analysis factors associated with mortality were old age patients (P = 0.02); history of pneumonia in last 12 months (P = 0.008); CURB 65 score ≥ 3 (P < 0.001) and high dependency units as initial site of care (P < 0.001). On multivariable analysis CURB65 ≥ 3 score; high dependency unit as initial site of care; bedridden status; presence of bilateral infiltrates on chest X-ray and hemoglobin of 10.4 g/dL or less at the time of admission were key determinants of in-hospital mortality. We found CURB65 ≥ 3 score; high dependency unit as initial site of care; bedridden status; bilateral infiltrates on chest X-ray and low hemoglobin (10.4 g/dL or less) at the time of admission as independent risk factors of in-hospital mortality. Staphylococcus aureus was the most common organism isolated in patients.
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
328-334Informations de copyright
© 2019 John Wiley & Sons Ltd.
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