Comparison of the toxicity of sulfur mustard and its oxidation products in vitro.
Antidotes
/ pharmacology
Cimetidine
/ pharmacology
Cytochrome P-450 CYP1A2
/ biosynthesis
Cytochrome P-450 CYP1A2 Inducers
/ pharmacology
Cytochrome P-450 CYP1A2 Inhibitors
/ pharmacology
Dose-Response Relationship, Drug
Hep G2 Cells
Hepatocytes
/ drug effects
Humans
Mustard Gas
/ metabolism
Nerve Agents
/ metabolism
Omeprazole
/ pharmacology
Oxidation-Reduction
Sulfones
/ metabolism
Sulfoxides
/ metabolism
CYP1A2
HepG2 cells
SM oxidation
SMO, SMO(2), DVS, cytotoxicity
Journal
Toxicology letters
ISSN: 1879-3169
Titre abrégé: Toxicol Lett
Pays: Netherlands
ID NLM: 7709027
Informations de publication
Date de publication:
15 Mar 2020
15 Mar 2020
Historique:
received:
26
09
2019
revised:
05
12
2019
accepted:
13
12
2019
pubmed:
22
12
2019
medline:
28
1
2020
entrez:
22
12
2019
Statut:
ppublish
Résumé
The molecular toxicology of the chemical warfare agent sulfur mustard (SM) is still not completely understood. It has been suggested that in addition to SM itself also biotransformation products thereof mediate cytotoxicity. In the current study, we assessed this aspect by exposing a human hepatocyte cell line (HepG2) to SM or to its oxidation products sulfur mustard sulfoxide (SMO), sulfur mustard sulfone (SMO
Identifiants
pubmed: 31863871
pii: S0378-4274(19)30408-4
doi: 10.1016/j.toxlet.2019.12.015
pii:
doi:
Substances chimiques
Antidotes
0
Cytochrome P-450 CYP1A2 Inducers
0
Cytochrome P-450 CYP1A2 Inhibitors
0
Nerve Agents
0
Sulfones
0
Sulfoxides
0
divinyl sulfone
5PFN71LP8M
Cimetidine
80061L1WGD
CYP1A2 protein, human
EC 1.14.14.1
Cytochrome P-450 CYP1A2
EC 1.14.14.1
Omeprazole
KG60484QX9
Mustard Gas
T8KEC9FH9P
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
69-72Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.