Advances in the diagnosis of autoimmune bullous dermatoses.
Journal
Clinics in dermatology
ISSN: 1879-1131
Titre abrégé: Clin Dermatol
Pays: United States
ID NLM: 8406412
Informations de publication
Date de publication:
Historique:
entrez:
23
12
2019
pubmed:
23
12
2019
medline:
18
8
2020
Statut:
ppublish
Résumé
Autoimmune bullous dermatoses are defined by autoantibodies directed against adhesion proteins in the epidermis or basement membrane zone, resulting in blister formation on the skin and mucosa. Diagnosis depends on lesional biopsy for histopathology and perilesional biopsy for direct immunofluorescence. Additional diagnostic methods include indirect immunofluorescence, enzyme-linked immunosorbent assay, and immunoblot (Western blot), which may be selected in specific clinical scenarios due to improved sensitivity and/or specificity. This contribution reviews the available evidence supporting the use of each method to provide a practical reference for clinicians when diagnosing autoimmune bullous disorders. Techniques and cost are reviewed, and newer diagnostic techniques with potential for clinical application are.
Identifiants
pubmed: 31864451
pii: S0738-081X(19)30176-2
doi: 10.1016/j.clindermatol.2019.09.004
pii:
doi:
Substances chimiques
Autoantibodies
0
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
692-712Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.