Long-term stability and characteristics of behavioral, biochemical, and molecular markers of three different rodent models for depression.
5-HT
UCMS
corticosterone
depression model
glucocorticoid
olfactory bulbectomy
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
22
08
2019
revised:
22
10
2019
accepted:
27
11
2019
pubmed:
24
12
2019
medline:
29
12
2020
entrez:
24
12
2019
Statut:
ppublish
Résumé
The present study was designed to explore the long-term differences between three mouse models for depression. In the present study, the unpredictable chronic mild stress (UCMS) model, the glucocorticoid/corticosterone model, and the olfactory bulbectomy model were compared at two, three, and five weeks after model induction. Behavioral testing performed included forced-swimming, tail suspension, open-field and elevated plus-maze tests. In addition, 5-hydroxytryptamine (5-HT) and dopamine levels, and mRNA and protein expressions related to 5-HT synthesis, transport, and signaling were analyzed in the hippocampus of tested animals. Our results revealed that each model demonstrated a specific profile of markers, whereas the stability of them differed over testing time. Each model provided a unique set of advantages that can be considered depending on the context and aims of each study. Among the three models, the UCMS model was mostly stable and appeared to the best model for testing long-term depression-like state.
Identifiants
pubmed: 31867894
doi: 10.1002/brb3.1508
pmc: PMC7010584
doi:
Substances chimiques
Biomarkers
0
Serotonin
333DO1RDJY
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e01508Subventions
Organisme : National Natural Science Foundation of China
ID : 81703734
Pays : International
Organisme : Shanghai Sailing Program
ID : 17YF1417700
Pays : International
Organisme : Program from Shanghai Municipal Commission of Health and Family Planning
ID : 20184Y0177
Pays : International
Organisme : Natural Science Foundation of Shanghai
ID : 17ZR1430200
Pays : International
Organisme : Shanghai Key Laboratory of Psychotic Disorders
ID : 16-K03
Pays : International
Informations de copyright
© 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
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