Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions.
Animals
Antigens, Ly
/ metabolism
Aorta
/ metabolism
Aortic Diseases
/ etiology
Atherosclerosis
/ etiology
Biomarkers
/ blood
Blood Glucose
/ metabolism
Bone Marrow Transplantation
CARD Signaling Adaptor Proteins
/ deficiency
Cells, Cultured
Collagen
/ metabolism
Cytokines
/ metabolism
Diabetes Mellitus, Experimental
/ blood
Diet, Western
Gene Deletion
Genetic Predisposition to Disease
Hematopoietic Stem Cells
/ metabolism
Lectins, C-Type
/ deficiency
Macrophages, Peritoneal
/ metabolism
Male
Mice, Inbred C57BL
Mice, Knockout
Monocytes
/ metabolism
Plaque, Atherosclerotic
Receptors, LDL
/ deficiency
Atherosclerosis
C-type lectin receptors
CARD9
Dectin-2
hyperglycaemia
inflammation
monocytes/macrophages
Journal
Diabetes & vascular disease research
ISSN: 1752-8984
Titre abrégé: Diab Vasc Dis Res
Pays: England
ID NLM: 101234011
Informations de publication
Date de publication:
Historique:
pubmed:
24
12
2019
medline:
1
7
2020
entrez:
24
12
2019
Statut:
ppublish
Résumé
C-type lectin receptors, including Dectin-2, are pattern recognition receptors on monocytes and macrophages that mainly recognize sugars and sugar-like structures present on fungi. Activation of C-type lectin receptors induces downstream CARD9 signalling, leading to the production of cytokines. We hypothesized that under hyperglycaemic conditions, as is the case in diabetes mellitus, glycosylated protein (sugar-like) structures activate C-type lectin receptors, leading to immune cell activation and increased atherosclerosis development. Low-density lipoprotein receptor-deficient mice were lethally irradiated and transplanted with bone marrow from control wild-type, Deletion of haematopoietic Dectin-2 reduced the number of circulating Ly6C
Sections du résumé
BACKGROUND
C-type lectin receptors, including Dectin-2, are pattern recognition receptors on monocytes and macrophages that mainly recognize sugars and sugar-like structures present on fungi. Activation of C-type lectin receptors induces downstream CARD9 signalling, leading to the production of cytokines. We hypothesized that under hyperglycaemic conditions, as is the case in diabetes mellitus, glycosylated protein (sugar-like) structures activate C-type lectin receptors, leading to immune cell activation and increased atherosclerosis development.
METHODS
Low-density lipoprotein receptor-deficient mice were lethally irradiated and transplanted with bone marrow from control wild-type,
RESULTS AND CONCLUSION
Deletion of haematopoietic Dectin-2 reduced the number of circulating Ly6C
Identifiants
pubmed: 31868000
doi: 10.1177/1479164119892140
pmc: PMC7510497
doi:
Substances chimiques
Antigens, Ly
0
Biomarkers
0
Blood Glucose
0
CARD Signaling Adaptor Proteins
0
Card9 protein, mouse
0
Cytokines
0
Lectins, C-Type
0
Ly-6C antigen, mouse
0
Receptors, LDL
0
dectin-2, mouse
0
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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