Activity of Chitosan and Its Derivatives against Leishmania major and Leishmania mexicana
Amphotericin B
/ pharmacology
Animals
Antiprotozoal Agents
/ pharmacology
Chitosan
/ analogs & derivatives
Culture Media
/ chemistry
Dose-Response Relationship, Drug
Female
Humans
Hydrogen-Ion Concentration
Leishmania major
/ drug effects
Leishmania mexicana
/ drug effects
Life Cycle Stages
/ drug effects
Macrophages
/ drug effects
Macrophages, Peritoneal
/ drug effects
Mice
Mice, Inbred BALB C
Molecular Weight
Nitric Oxide
/ metabolism
Parasitic Sensitivity Tests
Pinocytosis
/ drug effects
Primary Cell Culture
Reactive Oxygen Species
/ metabolism
THP-1 Cells
Tumor Necrosis Factor-alpha
/ biosynthesis
Leishmania major
Leishmania mexicana
chitosan
cutaneous leishmaniasis
macrophage uptake
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
21 02 2020
21 02 2020
Historique:
received:
03
09
2019
accepted:
08
12
2019
pubmed:
25
12
2019
medline:
19
12
2020
entrez:
25
12
2019
Statut:
epublish
Résumé
There is an urgent need for safe, efficacious, affordable, and field-adapted drugs for the treatment of cutaneous leishmaniasis, which newly affects around 1.5 million people worldwide annually. Chitosan, a biodegradable cationic polysaccharide, has previously been reported to have antimicrobial, antileishmanial, and immunostimulatory activities. We investigated the
Identifiants
pubmed: 31871082
pii: AAC.01772-19
doi: 10.1128/AAC.01772-19
pmc: PMC7038302
pii:
doi:
Substances chimiques
Antiprotozoal Agents
0
Culture Media
0
Reactive Oxygen Species
0
Tumor Necrosis Factor-alpha
0
Nitric Oxide
31C4KY9ESH
Amphotericin B
7XU7A7DROE
Chitosan
9012-76-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Riezk et al.
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