VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in
antibacterial
biochemistry
microbiology
structural biology
β-lactamases
β-lactams
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
21 02 2020
21 02 2020
Historique:
received:
30
09
2019
accepted:
11
12
2019
pubmed:
25
12
2019
medline:
22
12
2020
entrez:
25
12
2019
Statut:
epublish
Résumé
As shifts in the epidemiology of β-lactamase-mediated resistance continue, carbapenem-resistant
Identifiants
pubmed: 31871094
pii: AAC.01963-19
doi: 10.1128/AAC.01963-19
pmc: PMC7038240
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Borinic Acids
0
Carboxylic Acids
0
beta-Lactamase Inhibitors
0
Cefepime
807PW4VQE3
taniborbactam
8IGQ156Z07
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : 101999/Z/13/Z
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI089512
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201300019C
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : HHSN272201300019I
Pays : United States
Informations de copyright
Copyright © 2020 Hamrick et al.
Références
Nat Rev Microbiol. 2019 May;17(5):295-306
pubmed: 30837684
Antimicrob Agents Chemother. 2010 Aug;54(8):3197-204
pubmed: 20498317
Antimicrob Agents Chemother. 2015 Oct;59(10):6248-55
pubmed: 26248364
Diagn Microbiol Infect Dis. 2013 Feb;75(2):115-20
pubmed: 23290507
EBioMedicine. 2017 May;19:98-106
pubmed: 28479289
Emerg Infect Dis. 2019 Jun;25(6):1209-1213
pubmed: 31107227
J Med Chem. 2015 May 14;58(9):3682-92
pubmed: 25782055
ACS Infect Dis. 2018 Feb 9;4(2):84-87
pubmed: 29232103
Nat Rev Drug Discov. 2015 Jul;14(7):445-7
pubmed: 26129790
Antimicrob Agents Chemother. 2019 Sep 16;:
pubmed: 31527031
J Infect Chemother. 2018 Nov;24(11):915-920
pubmed: 30197092
Antimicrob Agents Chemother. 2017 Mar 24;61(4):
pubmed: 28115348
J Enzyme Inhib Med Chem. 2017 Dec;32(1):917-919
pubmed: 28719998
Drugs. 2018 Apr;78(6):675-692
pubmed: 29671219
S D Med. 2019 Mar;72(3):136-138
pubmed: 31018063
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14280-5
pubmed: 11724923
Trends Pharmacol Sci. 2018 Jul;39(7):635-647
pubmed: 29680579
Antimicrob Agents Chemother. 2014 May;58(5):2740-6
pubmed: 24566187
Int J Infect Dis. 2019 Aug;85:203-211
pubmed: 31229615
J Med Chem. 2019 Dec 16;:
pubmed: 31765155
Antimicrob Agents Chemother. 2013 Jun;57(6):2496-505
pubmed: 23439634
BMC Microbiol. 2017 Apr 27;17(1):101
pubmed: 28449650
Infect Control Hosp Epidemiol. 2019 Nov;40(11):1297-1300
pubmed: 31474240
Drug Resist Updat. 2016 Nov;29:30-46
pubmed: 27912842
Acta Pharm Sin B. 2016 Nov;6(6):552-556
pubmed: 27818921
Antimicrob Agents Chemother. 2015 Dec 07;60(2):1067-78
pubmed: 26643349
Ann Pharmacother. 2007 Nov;41(11):1859-66
pubmed: 17911203
J Mol Biol. 2008 Jan 18;375(3):604-11
pubmed: 18061205
J Antimicrob Chemother. 2013 Aug;68(8):1825-31
pubmed: 23580564
J Antimicrob Chemother. 2017 May 1;72(5):1340-1349
pubmed: 28199647
Int J Antimicrob Agents. 2015 Nov;46(5):483-93
pubmed: 26498989
J Glob Infect Dis. 2016 Jan-Mar;8(1):41-50
pubmed: 27013843
J Glob Antimicrob Resist. 2019 Dec;19:28-31
pubmed: 30825700
Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):386-94
pubmed: 21460457
J Antimicrob Chemother. 2018 Mar 1;73(3):658-663
pubmed: 29149337
Nat Commun. 2016 Aug 08;7:12406
pubmed: 27499424
Antimicrob Agents Chemother. 2009 Nov;53(11):4783-8
pubmed: 19738025
Antimicrob Agents Chemother. 2001 Mar;45(3):660-3
pubmed: 11181339
Virulence. 2017 May 19;8(4):460-469
pubmed: 27593176
ACS Infect Dis. 2019 Jan 11;5(1):9-34
pubmed: 30421910
J Biol Chem. 2013 Sep 27;288(39):27960-71
pubmed: 23913691
Antimicrob Agents Chemother. 2017 Feb 23;61(3):
pubmed: 28031201
Lancet Infect Dis. 2013 Oct;13(10):867-76
pubmed: 23845533
Antimicrob Agents Chemother. 2018 Sep 24;62(10):
pubmed: 30061284
Antimicrob Agents Chemother. 2017 Apr 24;61(5):
pubmed: 28223379
Infect Dis Clin North Am. 2016 Jun;30(2):441-464
pubmed: 27208767
Antimicrob Agents Chemother. 1999 Apr;43(4):902-6
pubmed: 10103197
Antimicrob Agents Chemother. 2010 Mar;54(3):969-76
pubmed: 19995920
Diagn Microbiol Infect Dis. 2017 Dec;89(4):305-309
pubmed: 28969934
Open Forum Infect Dis. 2015 May 05;2(2):ofv050
pubmed: 26125030