Site-Specific PEGylation of Anti-Mesothelin Recombinant Immunotoxins Increases Half-life and Antitumor Activity.
Animals
Antineoplastic Agents
/ chemistry
Apoptosis
Cell Proliferation
Female
GPI-Linked Proteins
/ antagonists & inhibitors
Half-Life
Humans
Immunotoxins
/ chemistry
Mesothelin
Mice
Mice, Nude
Pancreatic Neoplasms
/ drug therapy
Polyethylene Glycols
/ chemistry
Recombinant Proteins
/ chemistry
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Journal
Molecular cancer therapeutics
ISSN: 1538-8514
Titre abrégé: Mol Cancer Ther
Pays: United States
ID NLM: 101132535
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
13
09
2019
revised:
11
10
2019
accepted:
13
12
2019
pubmed:
25
12
2019
medline:
13
2
2021
entrez:
25
12
2019
Statut:
ppublish
Résumé
Recombinant immunotoxins (RIT) are chimeric proteins containing an Fv that binds to tumor cells, fused to a fragment of
Identifiants
pubmed: 31871266
pii: 1535-7163.MCT-19-0890
doi: 10.1158/1535-7163.MCT-19-0890
pmc: PMC7056543
mid: NIHMS1547063
doi:
Substances chimiques
Antineoplastic Agents
0
GPI-Linked Proteins
0
Immunotoxins
0
Msln protein, mouse
0
Recombinant Proteins
0
Polyethylene Glycols
3WJQ0SDW1A
Mesothelin
J27WDC343N
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
812-821Subventions
Organisme : Intramural NIH HHS
ID : Z01 BC008753
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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