Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy.
Genome-wide association studies
Retinal diseases
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
2019
2019
Historique:
received:
19
06
2019
accepted:
26
11
2019
entrez:
25
12
2019
pubmed:
25
12
2019
medline:
7
7
2020
Statut:
epublish
Résumé
The recently emerged pachychoroid concept has changed the understanding of age-related macular degeneration (AMD), which is a major cause of blindness; recent studies attributed AMD in part to pachychoroid disease central serous chorioretinopathy (CSC), suggesting the importance of elucidating the CSC pathogenesis. Our large genome-wide association study followed by validation studies in three independent Japanese and European cohorts, consisting of 1546 CSC samples and 13,029 controls, identified two novel CSC susceptibility loci:
Identifiants
pubmed: 31872073
doi: 10.1038/s42003-019-0712-z
pii: 712
pmc: PMC6908630
doi:
Banques de données
figshare
['10.6084/m9.figshare.11136047.v1']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
468Informations de copyright
© The Author(s) 2019.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing interests.
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