Intensive statin treatment ameliorate the Th17/Treg functional imbalance in patients with non-ST elevation acute coronary syndrome underwent percutaneous coronary intervention.
Acute Coronary Syndrome
/ diagnosis
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents
/ administration & dosage
CD4 Lymphocyte Count
China
Cytokines
/ blood
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/ administration & dosage
Male
Middle Aged
Non-ST Elevated Myocardial Infarction
/ diagnosis
Percutaneous Coronary Intervention
/ adverse effects
T-Lymphocytes, Regulatory
/ drug effects
Th17 Cells
/ drug effects
Time Factors
Treatment Outcome
Th17/Treg
acute coronary syndrome
inflammation
statin
Journal
Clinical cardiology
ISSN: 1932-8737
Titre abrégé: Clin Cardiol
Pays: United States
ID NLM: 7903272
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
23
09
2019
revised:
10
12
2019
accepted:
11
12
2019
pubmed:
25
12
2019
medline:
22
12
2020
entrez:
25
12
2019
Statut:
ppublish
Résumé
Inflammation plays important roles in the pathogenesis of acute coronary syndrome (ACS). Statins exert positive effects on the plaque stabilization through anti-inflammation, however, the detailed mechanism is still under investigation. Studies suggest that the Th17/Treg functional imbalance takes key part in the plaque destabilization and the onset of ACS. We hypothesized that intensive statin therapy could ameliorate the Th17/Treg imbalance in patients with ACS. Sixty-six patients with non-ST elevation acute coronary syndrome (NSTE-ACS) were randomized to conventional group and intensive group. Peripheral blood samples were collected on admission and after atorvastatin treatment. The frequencies of circulating Th17 cells and Treg cells, the levels of cytokines associated with Th17 cells (IL-17, IL-6 and IL-23) and associated with Treg cells (IL-10 and TGF-β1) were measured through flow cytometry and ELISA assay respectively. One week after therapy, the frequencies of circulating Th17 cells of both the groups decreased and the frequencies of circulating Treg cells increased significantly, compared with the basal levels. Furthermore, the decreased frequencies of circulating Th17 cells and the increased frequencies of circulating Treg cells in the intensive group were significantly higher than those in the conventional group. In consistence, the decreased accumulation of IL-17, IL-6 and IL-23 (cytokines relevant to Th17 cells) and the increased accumulation of IL-10 and TGF-β1 in peripheral blood were displayed in both groups. The changes are more significant in the intensive group. Intensive statins therapy could ameliorate the Th17 and Treg functional imbalance in patients with ACS.
Sections du résumé
BACKGROUND
BACKGROUND
Inflammation plays important roles in the pathogenesis of acute coronary syndrome (ACS). Statins exert positive effects on the plaque stabilization through anti-inflammation, however, the detailed mechanism is still under investigation.
HYPOTHESIS
OBJECTIVE
Studies suggest that the Th17/Treg functional imbalance takes key part in the plaque destabilization and the onset of ACS. We hypothesized that intensive statin therapy could ameliorate the Th17/Treg imbalance in patients with ACS.
METHODS
METHODS
Sixty-six patients with non-ST elevation acute coronary syndrome (NSTE-ACS) were randomized to conventional group and intensive group. Peripheral blood samples were collected on admission and after atorvastatin treatment. The frequencies of circulating Th17 cells and Treg cells, the levels of cytokines associated with Th17 cells (IL-17, IL-6 and IL-23) and associated with Treg cells (IL-10 and TGF-β1) were measured through flow cytometry and ELISA assay respectively.
RESULTS
RESULTS
One week after therapy, the frequencies of circulating Th17 cells of both the groups decreased and the frequencies of circulating Treg cells increased significantly, compared with the basal levels. Furthermore, the decreased frequencies of circulating Th17 cells and the increased frequencies of circulating Treg cells in the intensive group were significantly higher than those in the conventional group. In consistence, the decreased accumulation of IL-17, IL-6 and IL-23 (cytokines relevant to Th17 cells) and the increased accumulation of IL-10 and TGF-β1 in peripheral blood were displayed in both groups. The changes are more significant in the intensive group.
CONCLUSION
CONCLUSIONS
Intensive statins therapy could ameliorate the Th17 and Treg functional imbalance in patients with ACS.
Identifiants
pubmed: 31872906
doi: 10.1002/clc.23326
pmc: PMC7144487
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Cytokines
0
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
379-385Subventions
Organisme : National Natural Science Foundation of China
ID : 81770382
Informations de copyright
© 2019 The Authors. Clinical Cardiology published by Wiley Periodicals, Inc.
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