Extracellular signal-regulated kinase 1/2 regulates NAD metabolism during acute kidney injury through microRNA-34a-mediated NAMPT expression.
Acetylation
/ drug effects
Acute Kidney Injury
/ metabolism
Animals
Antagomirs
/ metabolism
Creatinine
/ blood
Cytokines
/ genetics
Disease Models, Animal
Gene Expression Regulation
/ drug effects
Kidney Cortex
/ metabolism
Male
Mice
Mice, Inbred C57BL
MicroRNAs
/ antagonists & inhibitors
Mitogen-Activated Protein Kinase 1
/ antagonists & inhibitors
Mitogen-Activated Protein Kinase 3
/ antagonists & inhibitors
NAD
/ metabolism
Nicotinamide Phosphoribosyltransferase
/ genetics
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
/ metabolism
Phosphorylation
/ drug effects
Pyridones
/ pharmacology
Pyrimidinones
/ pharmacology
Sirtuin 1
/ metabolism
Cellular metabolism
ERK1/2
Ischemia–reperfusion
Kidney
Mitochondrial biogenesis
Nicotinamide adenine dinucleotide
miR-34a
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
04
01
2019
accepted:
20
11
2019
revised:
26
10
2019
pubmed:
25
12
2019
medline:
9
9
2020
entrez:
25
12
2019
Statut:
ppublish
Résumé
Prior studies have established the important role of extracellular signal-regulated kinase 1/2 (ERK1/2) as a mediator of acute kidney injury (AKI). We demonstrated rapid ERK1/2 activation induced renal dysfunction following ischemia/reperfusion (IR)-induced AKI and downregulated the mitochondrial biogenesis (MB) regulator, peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) in mice. In this study, ERK1/2 regulation of cellular nicotinamide adenine dinucleotide (NAD) and PGC-1α were explored. Inhibition of ERK1/2 activation during AKI in mice using the MEK1/2 inhibitor, trametinib, attenuated renal cortical oxidized NAD (NAD
Identifiants
pubmed: 31873757
doi: 10.1007/s00018-019-03391-z
pii: 10.1007/s00018-019-03391-z
doi:
Substances chimiques
Antagomirs
0
Cytokines
0
MIRN34 microRNA, human
0
MicroRNAs
0
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
0
Ppargc1a protein, mouse
0
Pyridones
0
Pyrimidinones
0
NAD
0U46U6E8UK
trametinib
33E86K87QN
Creatinine
AYI8EX34EU
Nicotinamide Phosphoribosyltransferase
EC 2.4.2.12
nicotinamide phosphoribosyltransferase, mouse
EC 2.4.2.12
Mitogen-Activated Protein Kinase 1
EC 2.7.11.24
Mitogen-Activated Protein Kinase 3
EC 2.7.11.24
Sirt1 protein, mouse
EC 3.5.1.-
Sirtuin 1
EC 3.5.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3643-3655Subventions
Organisme : National Institutes of Health National Institute of General Medical Sciences
ID : R01GM084147
Organisme : Biomedical Laboratory Research and Development, VA Office of Research and Development
ID : BX000851
Organisme : National Institute of Diabetes and Digestive and Kidney Diseases
ID : F31DK105782
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