Nano-hydrogel embedded with quercetin and oleic acid as a new formulation in the treatment of diabetic foot ulcer: A pilot study.
hyaluronic acid
nano-hydrogel
oleic acid
quercetin
wound healing
Journal
International wound journal
ISSN: 1742-481X
Titre abrégé: Int Wound J
Pays: England
ID NLM: 101230907
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
21
11
2019
revised:
16
12
2019
accepted:
17
12
2019
pubmed:
27
12
2019
medline:
8
1
2021
entrez:
27
12
2019
Statut:
ppublish
Résumé
Wound healing, especially diabetic ones, is a relevant clinical problem, so it is not surprising that surgical procedures are often needed. To overcome invasive procedures, several strategies with drugs or natural compound are used. Recently, in an experimental study, we described an increase in keratinocyte proliferation after their exposition to quercetin plus oleic acid. In the present clinical study, we evaluated both the clinical efficacy and the safety of nano-hydrogel embedded with quercetin and oleic acid in the treatment of lower limb skin wound in patients with diabetes mellitus (DM). Fifty-six DM patients (28 men and 28 women, mean age 61.7 ± 9.2 years) unsuccessfully treated with mechanical compression were enrolled and randomised to receive an add on treatment with hyaluronic acid (0.2%) or nano-hydrogel embedded with quercetin and oleic acid. The treatment with nano-hydrogel embedded with quercetin and oleic acid significantly (P < .01) reduced the wound healing time, in comparison to hyaluronic acid (0.2%) without developing of adverse drug reactions, suggesting that this formulation could be used in the management of wound healing even if other clinical trials must be performed in order to validate this observation.
Identifiants
pubmed: 31876118
doi: 10.1111/iwj.13299
pmc: PMC7948574
doi:
Substances chimiques
Antioxidants
0
Drug Combinations
0
Hydrogels
0
Oleic Acid
2UMI9U37CP
Quercetin
9IKM0I5T1E
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
485-490Informations de copyright
© 2019 Medicalhelplines.com Inc and John Wiley & Sons Ltd.
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