Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation.
Adolescent
Age Factors
Child
Child, Preschool
Electroencephalography
Epilepsy
/ epidemiology
Europe
/ epidemiology
Female
Humans
Magnetic Resonance Imaging
Male
Neurosurgery
/ statistics & numerical data
Neurosurgical Procedures
/ statistics & numerical data
Retrospective Studies
Seizures
/ epidemiology
Temporal Lobe
/ diagnostic imaging
Treatment Outcome
children
epilepsy surgery
histopathology
outcome
survey
Journal
Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
02
08
2019
revised:
23
11
2019
accepted:
27
11
2019
pubmed:
27
12
2019
medline:
11
7
2020
entrez:
27
12
2019
Statut:
ppublish
Résumé
To profile European trends in pediatric epilepsy surgery (<16 years of age) between 2008 and 2015. We collected information on volumes and types of surgery, pathology, and seizure outcome from 20 recognized epilepsy surgery reference centers in 10 European countries. We analyzed retrospective aggregate data on 1859 operations. The proportion of surgeries significantly increased over time (P < .0001). Engel class I outcome was achieved in 69.3% of children, with no significant improvement between 2008 and 2015. The proportion of histopathological findings consistent with glial scars significantly increased between the ages of 7 and 16 years (P for trend = .0033), whereas that of the remaining pathologies did not vary across ages. A significant increase in unilobar extratemporal surgeries (P for trend = .0047) and a significant decrease in unilobar temporal surgeries (P for trend = .0030) were observed between 2008 and 2015. Conversely, the proportion of multilobar surgeries and unrevealing magnetic resonance imaging cases remained unchanged. Invasive investigations significantly increased, especially stereo-electroencephalography. We found different trends comparing centers starting their activity in the 1990s to those whose programs were developed in the past decade. Multivariate analysis revealed a significant variability of the proportion of the different pathologies and surgical approaches across countries, centers, and age groups between 2008 and 2015. Between 2008 and 2015, we observed a significant increase in the volume of pediatric epilepsy surgeries, stability in the proportion of Engel class I outcomes, and a modest increment in complexity of the procedures.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
216-227Investigateurs
Tom Jacques
(T)
Sophia Varadkar
(S)
Albert Colon
(A)
Piergiorgio D'Orio
(P)
Veronica Pelliccia
(V)
Andreas Schulze-Bonhage
(A)
Steffen Syrbe
(S)
Annamaria Buccoliero
(A)
Flavio Giordano
(F)
Marta García-Fernandez
(M)
Francisco Villarejo
(F)
Luca De Palma
(L)
Giusy Carfì Pavia
(G)
Nuno M Canas
(NM)
Alexandra Santos
(A)
Alexandra Montavont
(A)
Karine Ostrowsky-Coste
(K)
Kaloyan Gabrovski
(K)
Denitza Stoyanova
(D)
Giampiero Tamburrini
(G)
Tiziana Granata
(T)
Mattia Pacetti
(M)
Sara Matricardi
(S)
Dana Craiu
(D)
Angel Aledo
(A)
Irina Popa
(I)
Vincenzo Esposito
(V)
Ersilia Lucenteforte
(E)
Commentaires et corrections
Type : CommentIn
Informations de copyright
Wiley Periodicals, Inc. © 2019 International League Against Epilepsy.
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