Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574.

Animals Benzamides / chemistry Carbon-13 Magnetic Resonance Spectroscopy Cryoelectron Microscopy ERG1 Potassium Channel / agonists Humans Hydrophobic and Hydrophilic Interactions Molecular Dynamics Simulation Potassium Channel Blockers / chemistry Proton Magnetic Resonance Spectroscopy Small Molecule Libraries / chemistry Spectrometry, Mass, Electrospray Ionization Xenopus laevis

Journal

Journal of chemical information and modeling
ISSN: 1549-960X
Titre abrégé: J Chem Inf Model
Pays: United States
ID NLM: 101230060

Informations de publication

Date de publication:
27 01 2020
Historique:
pubmed: 27 12 2019
medline: 10 2 2021
entrez: 27 12 2019
Statut: ppublish

Résumé

Outward current conducted by human

Identifiants

DOI: 10.1021/acs.jcim.9b00737 PMID: 31877041
pubmed: 31877041
doi: 10.1021/acs.jcim.9b00737
doi:

Substances chimiques

3-nitro-N-(4-phenoxyphenyl)benzamide 0
Benzamides 0
ERG1 Potassium Channel 0
KCNH2 protein, human 0
Potassium Channel Blockers 0
Small Molecule Libraries 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

360-371

Subventions

Organisme : Austrian Science Fund FWF
ID : W 1232
Pays : Austria

Auteurs

Eva-Maria Zangerl-Plessl (EM)

Department of Pharmacology and Toxicology , University of Vienna , Althanstrasse 14 , Wien , Vienna 1090 , Austria.
ORCID: 0000-0002-2484-115X

Martin Berger (M)

Institute of Organic Chemistry , University of Vienna , Währinger Strasse 38 , Wien , Vienna 1090 , Austria.

Martina Drescher (M)

Institute of Organic Chemistry , University of Vienna , Währinger Strasse 38 , Wien , Vienna 1090 , Austria.

Yong Chen (Y)

Institute of Organic Chemistry , University of Vienna , Währinger Strasse 38 , Wien , Vienna 1090 , Austria.

Wei Wu (W)

Nora Eccles Harrison Cardiovascular Research and Training Institute and Division of Cardiovascular Medicine, Department of Internal Medicine , University of Utah , Salt Lake City , Utah 84132-340 , United States.

Nuno Maulide (N)

Institute of Organic Chemistry , University of Vienna , Währinger Strasse 38 , Wien , Vienna 1090 , Austria.
ORCID: 0000-0003-3643-0718

Michael Sanguinetti (M)

Nora Eccles Harrison Cardiovascular Research and Training Institute and Division of Cardiovascular Medicine, Department of Internal Medicine , University of Utah , Salt Lake City , Utah 84132-340 , United States.

Anna Stary-Weinzinger (A)

Department of Pharmacology and Toxicology , University of Vienna , Althanstrasse 14 , Wien , Vienna 1090 , Austria.
ORCID: 0000-0002-9202-0484

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Toward a Structural View of hERG Activation by...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Benzamides › Toward a Structural View of hERG Activation by...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Spectroscopie par résonance magnétique du carbone-13 › Toward a Structural View of hERG Activation by...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Toward a Structural View of hERG Activation by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Canaux potassiques éther-à-go-go › Canal potassique ERG1 › Toward a Structural View of hERG Activation by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Toward a Structural View of hERG Activation by...
questionsmedicales.fr › Phénomènes chimiques › Interactions hydrophobes et hydrophiles › Toward a Structural View of hERG Activation by...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Toward a Structural View of hERG Activation by...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Inhibiteurs des canaux potassiques › Toward a Structural View of hERG Activation by...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Spectroscopie par résonance magnétique du proton › Toward a Structural View of hERG Activation by...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Bibliothèques de petites molécules › Toward a Structural View of hERG Activation by...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse ESI › Toward a Structural View of hERG Activation by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Amphibiens › Anura › Pipidae › Xenopus › Xenopus laevis › Toward a Structural View of hERG Activation by...