Heterophilic cell-cell adhesion of atypical cadherins Fat and Dachsous regulate epithelial cell size dynamics during
Animals
Cadherins
/ metabolism
Cell Adhesion
Cell Adhesion Molecules
/ metabolism
Cell Polarity
Cell Size
Drosophila Proteins
/ metabolism
Drosophila melanogaster
/ cytology
Epithelial Cells
/ cytology
Epithelium
/ metabolism
Gene Knockdown Techniques
Models, Biological
Morphogenesis
Protein Multimerization
Pupa
/ metabolism
Thorax
/ growth & development
Journal
Molecular biology of the cell
ISSN: 1939-4586
Titre abrégé: Mol Biol Cell
Pays: United States
ID NLM: 9201390
Informations de publication
Date de publication:
19 03 2020
19 03 2020
Historique:
pubmed:
27
12
2019
medline:
23
1
2021
entrez:
27
12
2019
Statut:
ppublish
Résumé
Spatiotemporal changes in epithelial cell sizes-or epithelial cell size dynamics (ECD)-during morphogenesis entail interplay between two opposing forces: cell contraction via actomyosin cytoskeleton and cell expansion via cell-cell adhesion. Cell-cell adhesion-based ECD, however, has not yet been clearly demonstrated. For instance, changing levels of homophilic E-cadherin-based cell-cell adhesion induce cell sorting, but not ECD. Here we show that cell-expansive forces of heterophilic cell-cell adhesion regulate ECD: higher cell-cell adhesion results in cell size enlargement. Thus, ECD during morphogenesis in the heminotal epithelia of
Identifiants
pubmed: 31877063
doi: 10.1091/mbc.E19-08-0468
pmc: PMC7202070
doi:
Substances chimiques
Cadherins
0
Cell Adhesion Molecules
0
Drosophila Proteins
0
ds protein, Drosophila
0
ft protein, Drosophila
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
546-560Références
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