[Ethacrynic acid inhibits airway smooth muscle contraction in mice].

Animals Calcium / metabolism Calcium Channels, L-Type Enzyme Inhibitors / pharmacology Ethacrynic Acid / pharmacology Mice Muscle Contraction / drug effects Muscle, Smooth / drug effects Respiratory System / cytology

Journal

Sheng li xue bao : [Acta physiologica Sinica]
ISSN: 0371-0874
Titre abrégé: Sheng Li Xue Bao
Pays: China
ID NLM: 20730130R

Informations de publication

Date de publication:
25 Dec 2019
Historique:
entrez: 28 12 2019
pubmed: 28 12 2019
medline: 16 1 2020
Statut: ppublish

Résumé

The aim of this study was to investigate the inhibitory effect and the underlying mechanism of ethacrynic acid (EA) on the contraction in mice. BL-420S force measuring system was used to measure the tension of mouse tracheal rings. The whole cell patch clamp technique was utilized to record the channel currents of airway smooth muscle (ASM) cells. The calcium imaging system was used to determine the intracellular Ca

Identifiants

PMID: 31879742
pubmed: 31879742

Substances chimiques

Calcium Channels, L-Type 0
Enzyme Inhibitors 0
Ethacrynic Acid M5DP350VZV
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

chi

Sous-ensembles de citation

IM

Pagination

863-873

Auteurs

Xiao-Xue Zhao (XX)

Institute for Medical Biology & Hubei Province Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China; College of Life Sciences, South-Central University for Nationalities, Wuhan 430074, China.

Wei-Wei Chen (WW)

Institute for Medical Biology & Hubei Province Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China; College of Life Sciences, South-Central University for Nationalities, Wuhan 430074, China.

Yuan-Yuan Chen (YY)

Institute for Medical Biology & Hubei Province Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China; College of Life Sciences, South-Central University for Nationalities, Wuhan 430074, China.

Meng-Su Liu (MS)

Institute for Medical Biology & Hubei Province Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China; College of Life Sciences, South-Central University for Nationalities, Wuhan 430074, China.

Meng-Yue Li (MY)

Institute for Medical Biology & Hubei Province Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China; College of Life Sciences, South-Central University for Nationalities, Wuhan 430074, China.

Lei Cao (L)

Institute for Medical Biology & Hubei Province Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China; College of Life Sciences, South-Central University for Nationalities, Wuhan 430074, China.

Qing-Hua Liu (QH)

Institute for Medical Biology & Hubei Province Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China; College of Life Sciences, South-Central University for Nationalities, Wuhan 430074, China. liu258q@yahoo.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › [Ethacrynic acid inhibits airway smooth muscle...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › [Ethacrynic acid inhibits airway smooth muscle...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canaux calciques de type L › [Ethacrynic acid inhibits airway smooth muscle...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › [Ethacrynic acid inhibits airway smooth muscle...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Glycolates › Phénoxy-acétates › Acide étacrynique › [Ethacrynic acid inhibits airway smooth muscle...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › [Ethacrynic acid inhibits airway smooth muscle...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › [Ethacrynic acid inhibits airway smooth muscle...
questionsmedicales.fr › Tissus › Muscles › Muscles lisses › [Ethacrynic acid inhibits airway smooth muscle...
questionsmedicales.fr › Appareil respiratoire › [Ethacrynic acid inhibits airway smooth muscle...