Olfactory-Related Quality of Life in Multiple Chemical Sensitivity: A Genetic-Acquired Factors Model.
Adult
Alleles
Cytochrome P-450 Enzyme System
/ genetics
Environmental Exposure
Female
Gene Frequency
Genotype
Glutathione Transferase
/ genetics
Humans
Inactivation, Metabolic
Male
Middle Aged
Multiple Chemical Sensitivity
/ genetics
Polymorphism, Genetic
Quality of Life
Regression Analysis
Superoxide Dismutase
/ genetics
environmental exposure
genotype analysis
multiple chemical sensitivity
olfactory disorder
quality of life
xenobiotics detoxification
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Dec 2019
25 Dec 2019
Historique:
received:
05
12
2019
revised:
21
12
2019
accepted:
24
12
2019
entrez:
29
12
2019
pubmed:
29
12
2019
medline:
7
5
2020
Statut:
epublish
Résumé
Genetic polymorphisms as well as environmental exposures to chemical compounds, iatrogenic, psychological, and physical trauma may play a pathophysiological role in multiple chemical sensitivity (MCS) olfactory complaints, given that xenobiotic metabolism is influenced by sequence variations in genes of metabolizing enzymes. Thus, the aim of the present study was to depict-by means of multiple regression analysis-how different genetic conditions, grouped according to their function as well as clinical background and environmental exposure may interfere with those olfactory complaints referred by MCS patients. Therefore, MCS patients after gene polymorphism sequencing, the olfactory-related quality of life score-calculated by means of the Questionnaire of Olfactory Disorder in forty-six MCS patients-have been found to significantly rely on the phase I and II enzymes score and exposure to previous compounds and surgical treatments. The present work-implementing for the first time a genetic-acquired factors model on a regression analysis-further reinforces those theories, positing MCS as a complex, multifactorial, disease in which the genetic risk related to phase I and II enzymes involved in xenobiotic detoxification, olfactory, and neurodegenerative diseases play a necessary, but probably not sufficient role, along the pathophysiological route of the disease.
Identifiants
pubmed: 31881664
pii: ijms21010156
doi: 10.3390/ijms21010156
pmc: PMC6981591
pii:
doi:
Substances chimiques
Cytochrome P-450 Enzyme System
9035-51-2
Superoxide Dismutase
EC 1.15.1.1
superoxide dismutase 2
EC 1.15.1.1
Glutathione Transferase
EC 2.5.1.18
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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