Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response.
cancer
immunity
lactate
metabolism
microenvironment
nutrients
tumor acidity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Dec 2019
25 Dec 2019
Historique:
received:
15
11
2019
revised:
04
12
2019
accepted:
06
12
2019
entrez:
29
12
2019
pubmed:
29
12
2019
medline:
7
5
2020
Statut:
epublish
Résumé
Immune cells survey and patrol throughout the body and sometimes take residence in niche environments with distinct cellular subtypes and nutrients that may fluctuate from those in which they matured. Rooted in immune cell physiology are metabolic pathways and metabolites that not only deliver substrates and energy for growth and survival, but also instruct effector functions and cell differentiation. Unlike cancer cells, immune cells are not subject to a "Darwinian evolutionary pressure" that would allow them to adapt to developing tumors but are often irrevocably affected to local nutrient deprivation. Thus, immune cells must metabolically adapt to these changing conditions in order to perform their necessary functions. On the other hand, there is now a growing appreciation that metabolic changes occurring in cancer cells can impact on immune cell functionality and contribute to tumor immune evasion, and as such, there is a considerable and growing interest in developing techniques that target metabolism for immunotherapy. In this review, we discuss the metabolic plasticity displayed by innate and adaptive immune cells and highlight how tumor-derived lactate and tumor acidity restrict immunity. To our knowledge, this review outlines the most recent insights on how tumor microenvironment metabolically instructs immune responsiveness.
Identifiants
pubmed: 31881671
pii: ijms21010157
doi: 10.3390/ijms21010157
pmc: PMC6982275
pii:
doi:
Substances chimiques
Amino Acids
0
Lactic Acid
33X04XA5AT
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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