Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells.

Animals Cell Lineage / immunology Cells, Cultured GATA3 Transcription Factor / biosynthesis Inhibitor of Differentiation Protein 2 / metabolism Interleukin Receptor Common gamma Subunit / genetics Mice Mice, Inbred C57BL Mice, Knockout Nuclear Receptor Subfamily 1, Group F, Member 3 / biosynthesis Programmed Cell Death 1 Receptor / biosynthesis Promyelocytic Leukemia Zinc Finger Protein / biosynthesis Stem Cells / cytology T-Lymphocyte Subsets / cytology T-Lymphocytes, Helper-Inducer / cytology
cell fate bifurcation gene expression innate lymphoid cell lineage commitment lymphocyte development lymphoid tissue inducer lymphopoiesis progenitor heterogeneity transcription factor transcriptional regulation

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
14 01 2020
Historique:
received: 24 04 2019
revised: 18 09 2019
accepted: 03 12 2019
pubmed: 29 12 2019
medline: 6 2 2020
entrez: 29 12 2019
Statut: ppublish

Résumé

Lymphoid tissue inducer (LTi) cells are regarded as a subset of innate lymphoid cells (ILCs). However, these cells are not derived from the ILC common progenitor, which generates other ILC subsets and is defined by the expression of the transcription factor PLZF. Here, we examined transcription factor(s) determining the fate of LTi progenitors versus non-LTi ILC progenitors. Conditional deletion of Gata3 resulted in the loss of PLZF

Identifiants

DOI: 10.1016/j.immuni.2019.12.001 PMID: 31882362 PMC: PMC6962539
pubmed: 31882362
pii: S1074-7613(19)30497-2
doi: 10.1016/j.immuni.2019.12.001
pmc: PMC6962539
mid: NIHMS1546274
pii:
doi:

Substances chimiques

GATA3 Transcription Factor 0
Gata3 protein, mouse 0
Idb2 protein, mouse 0
Il2rg protein, mouse 0
Inhibitor of Differentiation Protein 2 0
Interleukin Receptor Common gamma Subunit 0
Nuclear Receptor Subfamily 1, Group F, Member 3 0
Pdcd1 protein, mouse 0
Programmed Cell Death 1 Receptor 0
Promyelocytic Leukemia Zinc Finger Protein 0
Rorc protein, mouse 0
Zbtb16 protein, mouse 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

83-95.e4

Subventions

Organisme : Intramural NIH HHS
ID : ZIA HL006031-10
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA HL006031
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AI001169-07
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AI001169
Pays : United States
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Références

Cytokine Growth Factor Rev. 2018 Aug;42:5-12
pubmed: 29454785
J Exp Med. 2006 Apr 17;203(4):1105-16
pubmed: 16606668
Immunity. 2014 Sep 18;41(3):354-365
pubmed: 25238093
Nat Rev Immunol. 2003 Apr;3(4):292-303
pubmed: 12669020
Immunity. 2012 Oct 19;37(4):634-48
pubmed: 23063333
Nature. 2016 Nov 3;539(7627):102-106
pubmed: 27749818
Immunity. 2018 Feb 20;48(2):227-242.e8
pubmed: 29466755
Nat Immunol. 2016 Jun 21;17(7):775-82
pubmed: 27328007
Immunity. 2013 Apr 18;38(4):694-704
pubmed: 23601684
Nat Immunol. 2016 Feb;17(2):169-78
pubmed: 26595886
Cell. 2014 Apr 10;157(2):340-356
pubmed: 24725403
Bioinformatics. 2016 Apr 15;32(8):1241-3
pubmed: 26668002
Cell. 2016 May 19;165(5):1120-1133
pubmed: 27156451
Nat Protoc. 2014 Jan;9(1):171-81
pubmed: 24385147
Blood. 2014 Sep 4;124(10):1586-96
pubmed: 25051963
Immunity. 2019 Apr 16;50(4):1054-1068.e3
pubmed: 30926235
Nature. 2014 Apr 17;508(7496):397-401
pubmed: 24509713
Nat Immunol. 2016 Mar;17(3):269-76
pubmed: 26779601
Nature. 1999 Feb 25;397(6721):702-6
pubmed: 10067894
Nat Immunol. 2009 Aug;10(8):840-7
pubmed: 19597498
Eur J Immunol. 2013 Apr;43(4):918-28
pubmed: 23310955
J Exp Med. 2014 Feb 10;211(2):199-208
pubmed: 24419270
Protein Cell. 2017 Apr;8(4):242-254
pubmed: 28108952
Immunity. 2012 Oct 19;37(4):649-59
pubmed: 23063330
J Exp Med. 2015 Oct 19;212(11):1869-82
pubmed: 26458769
J Immunol. 2013 Aug 15;191(4):1818-26
pubmed: 23851685
J Exp Med. 2017 Jul 3;214(7):1861-1876
pubmed: 28630089
Nat Immunol. 2018 Oct;19(10):1093-1099
pubmed: 30201992
Immunity. 2001 Aug;15(2):303-11
pubmed: 11520464
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Nat Immunol. 2016 Feb;17(2):179-86
pubmed: 26595889
Nat Rev Immunol. 2009 Feb;9(2):125-35
pubmed: 19151747
J Exp Med. 2015 Jun 1;212(6):875-82
pubmed: 25964370
Cell. 2016 May 19;165(5):1134-1146
pubmed: 27156452
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
Immunity. 2015 Aug 18;43(2):354-68
pubmed: 26231117
J Exp Med. 2009 Dec 21;206(13):2987-3000
pubmed: 19934022
Int Immunol. 2019 Jul 30;31(8):489-498
pubmed: 30783658
Nat Methods. 2008 Jul;5(7):621-8
pubmed: 18516045
Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10240-5
pubmed: 23733962
Nat Immunol. 2015 Jun;16(6):599-608
pubmed: 25915732
Nat Immunol. 2008 Oct;9(10):1122-30
pubmed: 18776904
Nat Immunol. 2004 Jan;5(1):64-73
pubmed: 14691482
Immunity. 2014 Mar 20;40(3):378-88
pubmed: 24631153
J Exp Med. 2018 Jan 2;215(1):249-262
pubmed: 29183988
J Exp Med. 2015 Jun 1;212(6):865-74
pubmed: 25964371
Nat Immunol. 2015 Oct;16(10):1044-50
pubmed: 26280998
Nature. 2015 Jan 15;517(7534):293-301
pubmed: 25592534
Nat Immunol. 2019 Aug;20(8):992-1003
pubmed: 31263279
Cell Rep. 2016 Oct 4;17(2):436-447
pubmed: 27705792
Nat Immunol. 2004 Nov;5(11):1157-65
pubmed: 15475959
Immunity. 2019 Jul 16;51(1):104-118.e7
pubmed: 31128961

Auteurs

Chao Zhong (C)

Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Institute of Systems Biomedicine, Department of Immunology, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing 100191, PRC. Electronic address: zhongc@hsc.pku.edu.cn.

Mingzhu Zheng (M)

Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Kairong Cui (K)

Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Andrew J Martins (AJ)

Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Gangqing Hu (G)

Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA; Department of Microbiology, Immunology, and Cell Biology, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.

Dan Li (D)

Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, PRC; Department of Clinical Laboratory, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, PRC.

Lino Tessarollo (L)

Mouse Cancer Genetics Program, Center for Cancer Research, NCI, Frederick, MD 21702, USA.

Serguei Kozlov (S)

Center for Advanced Preclinical Research, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

Jonathan R Keller (JR)

Mouse Cancer Genetics Program, Center for Cancer Research, NCI, Frederick, MD 21702, USA; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

John S Tsang (JS)

Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Keji Zhao (K)

Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Jinfang Zhu (J)

Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: jfzhu@niaid.nih.gov.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Differential Expression of the Transcription...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Lignage cellulaire › Differential Expression of the Transcription...
questionsmedicales.fr › Cellules › Cellules cultivées › Differential Expression of the Transcription...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription GATA › Facteur de transcription GATA-3 › Differential Expression of the Transcription...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines d'inhibition de la différenciation › Protéine d'inhibition de la différenciation-2 › Differential Expression of the Transcription...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Récepteurs à l'interleukine-21 › Sous-unité gamma commune aux récepteurs des interleukines › Differential Expression of the Transcription...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Differential Expression of the Transcription...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Differential Expression of the Transcription...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Differential Expression of the Transcription...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires › Differential Expression of the Transcription...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Récepteur-1 de mort cellulaire programmée › Differential Expression of the Transcription...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription Krüppel-like › Protéine à doigts de zinc de la leucémie promyélocytaire › Differential Expression of the Transcription...
questionsmedicales.fr › Cellules › Cellules souches › Differential Expression of the Transcription...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Differential Expression of the Transcription...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Differential Expression of the Transcription...