Severe Hypoglycemia and Cognitive Function in Older Adults With Type 1 Diabetes: The Study of Longevity in Diabetes (SOLID).
Aged
Aged, 80 and over
Aging
/ physiology
Cognition
/ physiology
Cognition Disorders
/ complications
Cognitive Dysfunction
/ complications
Cohort Studies
Diabetes Mellitus, Type 1
/ complications
Executive Function
/ physiology
Female
Humans
Hypoglycemia
/ complications
Longevity
/ physiology
Male
Middle Aged
Prospective Studies
Severity of Illness Index
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
05
05
2019
accepted:
06
11
2019
pubmed:
29
12
2019
medline:
2
12
2020
entrez:
29
12
2019
Statut:
ppublish
Résumé
In children with type 1 diabetes (T1D), severe hypoglycemia (SH) is associated with poorer cognition, but the association of SH with cognitive function in late life is unknown. Given the increasing life expectancy in people with T1D, understanding the role of SH in brain health is crucial. We examined the association between SH and cognitive function in 718 older adults with T1D from the Study of Longevity in Diabetes (SOLID). Subjects self-reported recent SH (previous 12 months) and lifetime history of SH resulting in inpatient/emergency department utilization. Global and domain-specific cognition (language, executive function, episodic memory, and simple attention) were assessed. The associations of SH with cognitive function and impaired cognition were evaluated via linear and logistic regression models, respectively. Thirty-two percent of participants (mean age 67.2 years) reported recent SH and 50% reported lifetime SH. Compared with those with no SH, subjects with a recent SH history had significantly lower global cognition scores. Domain-specific analyses revealed significantly lower scores on language, executive function, and episodic memory with recent SH exposure and significantly lower executive function with lifetime SH exposure. Recent SH was associated with impaired global cognition (odds ratio [OR] 3.22, 95% CI 1.30, 7.94) and cognitive impairment on the language domain (OR 3.15, 95% CI 1.19, 8.29). Among older adults with T1D, recent SH and lifetime SH were associated with worse cognition. Recent SH was associated with impaired global cognition. These findings suggest a deleterious role of SH on the brain health of older patients with T1D and highlight the importance of SH prevention.
Identifiants
pubmed: 31882410
pii: dc19-0906
doi: 10.2337/dc19-0906
pmc: PMC7035586
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
541-548Subventions
Organisme : NIA NIH HHS
ID : R01 AG047500
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 by the American Diabetes Association.
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