Interplay of Placental DNA Methylation and Maternal Insulin Sensitivity in Pregnancy.
Adult
Birth Weight
Blood Glucose
/ metabolism
CpG Islands
DNA Methylation
Diabetes, Gestational
/ genetics
Female
Genomic Imprinting
Glucose Tolerance Test
Humans
Infant, Newborn
Insulin
/ metabolism
Insulin Resistance
/ genetics
KCNQ1 Potassium Channel
/ genetics
Linear Models
Male
Mendelian Randomization Analysis
MicroRNAs
/ genetics
Nerve Tissue Proteins
/ genetics
Placenta
/ metabolism
Pregnancy
/ metabolism
RNA, Long Noncoding
/ genetics
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
10
08
2019
accepted:
24
12
2019
pubmed:
29
12
2019
medline:
4
8
2020
entrez:
29
12
2019
Statut:
ppublish
Résumé
The placenta participates in maternal insulin sensitivity changes during pregnancy; however, mechanisms remain unclear. We investigated associations between maternal insulin sensitivity and placental DNA methylation markers across the genome. We analyzed data from 430 mother-offspring dyads in the Gen3G cohort. All women underwent 75-g oral glucose tolerance tests at ∼26 weeks of gestation; we used glucose and insulin measures to estimate insulin sensitivity (Matsuda index). At delivery, we collected samples from placenta (fetal side) and measured DNA methylation using Illumina EPIC arrays. Using linear regression models to quantify associations at 720,077 cytosine-guanine dinucleotides (CpGs), with adjustment for maternal age, gravidity, smoking, BMI, child sex, and gestational age at delivery, we identified 188 CpG sites where placental DNA methylation was associated with Matsuda index (
Identifiants
pubmed: 31882564
pii: db19-0798
doi: 10.2337/db19-0798
pmc: PMC7213861
doi:
Substances chimiques
Blood Glucose
0
DLGAP2 protein, human
0
H19 long non-coding RNA
0
Insulin
0
KCNQ1 Potassium Channel
0
KCNQ1 protein, human
0
MIRN675 microRNA, human
0
MicroRNAs
0
Nerve Tissue Proteins
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
484-492Subventions
Organisme : NIDDK NIH HHS
ID : K23 DK113218
Pays : United States
Organisme : NIDDK NIH HHS
ID : L30 DK114998
Pays : United States
Organisme : CIHR
ID : MOP 115071
Pays : Canada
Informations de copyright
© 2019 by the American Diabetes Association.
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