Mechanistic insight into how gonadotropin hormone receptor complexes direct signaling†.
cross talk
dimer
follicle stimulating hormone receptor
gonadotropin hormone receptors
gonadotropin hormones
heteromer
homomer
luteinizing hormone receptor
oligomer
signaling
Journal
Biology of reproduction
ISSN: 1529-7268
Titre abrégé: Biol Reprod
Pays: United States
ID NLM: 0207224
Informations de publication
Date de publication:
15 04 2020
15 04 2020
Historique:
received:
03
10
2019
revised:
09
12
2019
accepted:
17
12
2019
pubmed:
29
12
2019
medline:
25
8
2021
entrez:
29
12
2019
Statut:
ppublish
Résumé
Gonadotropin hormones and their receptors play a central role in the control of male and female reproduction. In recent years, there has been growing evidence surrounding the complexity of gonadotropin hormone/receptor signaling, with it increasingly apparent that the Gαs/cAMP/PKA pathway is not the sole signaling pathway that confers their biological actions. Here we review recent literature on the different receptor-receptor, receptor-scaffold, and receptor-signaling molecule complexes formed and how these modulate and direct gonadotropin hormone-dependent intracellular signal activation. We will touch upon the more controversial issue of extragonadal expression of FSHR and the differential signal pathways activated in these tissues, and lastly, highlight the open questions surrounding the role these gonadotropin hormone receptor complexes and how this will shape future research directions.
Identifiants
pubmed: 31882999
pii: 5688713
doi: 10.1093/biolre/ioz228
pmc: PMC7608586
doi:
Substances chimiques
Receptors, Gonadotropin
0
Gonadotropin-Releasing Hormone
33515-09-2
Luteinizing Hormone
9002-67-9
Follicle Stimulating Hormone
9002-68-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
773-783Subventions
Organisme : NIA NIH HHS
ID : P01 AG029531
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R015961/1
Pays : United Kingdom
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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