T-cell exhaustion in HIV infection.
Anti-Retroviral Agents
/ therapeutic use
Antigens, Viral
/ immunology
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Disease Progression
HIV Infections
/ drug therapy
HIV-1
/ drug effects
Host-Pathogen Interactions
/ drug effects
Humans
Lymphocyte Activation
/ immunology
HIV
PD-1
T-cell exhaustion
chronic viral infection
immune checkpoint inhibitors
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
03
07
2019
accepted:
04
11
2019
entrez:
29
12
2019
pubmed:
29
12
2019
medline:
6
5
2020
Statut:
ppublish
Résumé
The T-cell response is central in the adaptive immune-mediated elimination of pathogen-infected and/or cancer cells. This activated T-cell response can inflict an overwhelming degree of damage to the targeted cells, which in most instances leads to the control and elimination of foreign invaders. However, in conditions of chronic infection, persistent exposure of T cells to high levels of antigen results in a severe T-cell dysfunctional state called exhaustion. T-cell exhaustion leads to a suboptimal immune-mediated control of multiple viral infections including the human immunodeficiency virus (HIV). In this review, we will discuss the role of T-cell exhaustion in HIV disease progression, the long-term defect of T-cell function even in aviremic patients on antiretroviral therapy (ART), the role of exhaustion-specific markers in maintaining a reservoir of latently infected cells, and exploiting these markers in HIV cure strategies.
Identifiants
pubmed: 31883174
doi: 10.1111/imr.12823
pmc: PMC7003858
doi:
Substances chimiques
Anti-Retroviral Agents
0
Antigens, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
149-163Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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