TRIM59 expression is regulated by Sp1 and Nrf1 in LPS-activated macrophages through JNK signaling pathway.
Animals
Atherosclerosis
/ pathology
Base Sequence
Disease Progression
Gene Expression Regulation
/ drug effects
Humans
Intracellular Signaling Peptides and Proteins
/ genetics
Lipopolysaccharides
/ pharmacology
MAP Kinase Signaling System
/ drug effects
Macrophage Activation
/ drug effects
Macrophages
/ drug effects
Male
Mice
Mice, Inbred C57BL
Models, Biological
NF-E2-Related Factor 1
/ metabolism
Promoter Regions, Genetic
Protein Transport
/ drug effects
RAW 264.7 Cells
Sp1 Transcription Factor
/ metabolism
Transcription, Genetic
/ drug effects
Tripartite Motif Proteins
/ genetics
Atherosclerosis
Macrophage
Nrf1
Sp1
TRIM59
Journal
Cellular signalling
ISSN: 1873-3913
Titre abrégé: Cell Signal
Pays: England
ID NLM: 8904683
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
29
11
2019
revised:
23
12
2019
accepted:
23
12
2019
pubmed:
29
12
2019
medline:
10
6
2021
entrez:
29
12
2019
Statut:
ppublish
Résumé
Activated macrophages play an important role in many inflammatory diseases including septic shock and atherosclerosis. TRIM59 has been showed to participate in many pathological processes, such as inflammation, cytotoxicity and tumorigenesis. However, the molecular mechanisms controlling its expression in activated macrophages are not fully understood. Here we report that TRIM59 expression is regulated by Sp1 and Nrf1 in LPS-activated macrophages. TRIM59 is highly expressed in macrophages, and markedly decreased by LPS stimuli in vivo and in vitro. TRIM59 promoter activity is also significantly suppressed by LPS and further analysis demonstrated that Sp1 and Nrf1 directly bound to the proximal promoter of TRIM59 gene. LPS treatment significantly decreased Sp1 expression, nuclear translocation and reduced its binding to the promoter, whereas increased Nrf1 expression, nuclear translocation and enhanced its binding to the promoter. Moreover, LPS-decreased TRIM59 expression was reversed by JNK inhibitor. Finally, TRIM59 level is significantly decreased during atherosclerosis progression. Taken together, our results demonstrated that TRIM59 expression was precisely regulated by Sp1 and Nrf1 in LPS-activated macrophages, which may be dependent on the activation of JNK signaling pathway and TRIM59 may be a potential therapeutic target for inflammatory diseases such as atherosclerosis.
Identifiants
pubmed: 31883458
pii: S0898-6568(19)30318-3
doi: 10.1016/j.cellsig.2019.109522
pmc: PMC7773022
mid: NIHMS1656041
pii:
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Lipopolysaccharides
0
NF-E2-Related Factor 1
0
Nfe2L1 protein, mouse
0
Sp1 Transcription Factor
0
Trim59 protein, mouse
0
Tripartite Motif Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109522Subventions
Organisme : NIAID NIH HHS
ID : R15 AI138116
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Références
Annu Rev Pharmacol Toxicol. 1995;35:655-77
pubmed: 7598511
Gene. 2016 Jun 10;584(1):17-25
pubmed: 26947393
Sci Rep. 2013;3:2006
pubmed: 23774320
Cancer Res. 2018 Apr 1;78(7):1792-1804
pubmed: 29386185
Biochim Biophys Acta. 2013 Jun;1831(6):1134-45
pubmed: 23466610
Gene. 2012 Oct 15;508(1):1-8
pubmed: 22835698
Microbiol Mol Biol Rev. 2011 Mar;75(1):50-83
pubmed: 21372320
J Biol Chem. 2007 Dec 21;282(51):36837-44
pubmed: 17928287
Nature. 2003 Dec 18;426(6968):895-9
pubmed: 14685250
J Immunol. 2000 Oct 1;165(7):3541-4
pubmed: 11034352
Gastroenterology. 2014 Nov;147(5):1043-54
pubmed: 25046164
Life Sci. 2008 Aug 29;83(9-10):305-12
pubmed: 18664368
Sci Rep. 2017 Feb 17;7:42781
pubmed: 28211536
Mol Cell Biol. 2014 Oct;34(20):3800-16
pubmed: 25092871
Cell Death Dis. 2018 Feb 21;9(3):302
pubmed: 29467473
Connect Tissue Res. 2014 Aug;55 Suppl 1:107-12
pubmed: 25158192
Mol Cell Endocrinol. 2002 Sep 30;195(1-2):27-38
pubmed: 12354670
Oncogene. 2006 Oct 30;25(51):6680-4
pubmed: 17072321
J Leukoc Biol. 2002 Sep;72(3):417-28
pubmed: 12223508
Nat Rev Immunol. 2013 Oct;13(10):709-21
pubmed: 23995626
Biochem Biophys Res Commun. 2012 Jun 8;422(3):501-7
pubmed: 22588174
J Biol Chem. 2009 Jun 5;284(23):15475-86
pubmed: 19318349
Circulation. 2004 Nov 30;110(22):3472-9
pubmed: 15557368
Nature. 2008 Jul 24;454(7203):428-35
pubmed: 18650913
Free Radic Biol Med. 2018 Mar;117:37-44
pubmed: 29421237
Int Immunopharmacol. 2014 Jun;20(2):298-306
pubmed: 24735815
J Immunol. 1999 Dec 15;163(12):6403-12
pubmed: 10586030
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8408-13
pubmed: 21536885
J Biol Chem. 2016 Aug 12;291(33):16977-89
pubmed: 27358406
Toxicol Appl Pharmacol. 2010 Apr 1;244(1):16-20
pubmed: 19665035
Circulation. 2015 Jan 27;131(4):e29-322
pubmed: 25520374
Environ Health Perspect. 2011 Jan;119(1):56-62
pubmed: 20805060
Onco Targets Ther. 2017 Mar 09;10:1503-1512
pubmed: 28331343
Mediators Inflamm. 2014;2014:983401
pubmed: 24803746
Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L847-53
pubmed: 25659903
Antioxid Redox Signal. 2015 Apr 1;22(10):819-31
pubmed: 25556857
Mol Endocrinol. 2005 Oct;19(10):2466-77
pubmed: 16051664
J Biol Chem. 2004 Oct 29;279(44):45423-32
pubmed: 15308669
Elife. 2014;3:e01856
pubmed: 24448410
Exp Cell Res. 2014 Mar 10;322(1):39-50
pubmed: 24462598
Nat Immunol. 2011 Jul 19;12(8):715-23
pubmed: 21772280
Biochem J. 2009 Mar 1;418(2):293-310
pubmed: 18990090
Mol Cell Biol. 2012 Jul;32(14):2760-70
pubmed: 22586274
Cell. 2017 Nov 16;171(5):1094-1109.e15
pubmed: 29149604
Circulation. 2017 Aug 8;136(6):566-582
pubmed: 28487392
J Neurochem. 2003 Jan;84(2):413-6
pubmed: 12559004
Mol Cells. 2012 Sep;34(3):263-70
pubmed: 22949172
Autophagy. 2018;14(12):2035-2048
pubmed: 30231667
Genes Cells. 2014 Aug;19(8):650-65
pubmed: 25041126
Circ Res. 2017 Oct 13;121(9):1047-1057
pubmed: 28827412
Mol Biol Cell. 2008 Mar;19(3):1139-51
pubmed: 18199680
Nat Rev Cancer. 2011 Oct 07;11(11):792-804
pubmed: 21979307
J Biol Chem. 2002 Aug 30;277(35):31863-70
pubmed: 12089157
J Biol Chem. 2011 Feb 4;286(5):3829-38
pubmed: 21115498
Biochim Biophys Acta. 2015 Oct;1849(10):1260-76
pubmed: 26254094
Nucleic Acids Res. 1998 Dec 1;26(23):5480-5
pubmed: 9826775
Biochem J. 2013 Sep 15;454(3):467-77
pubmed: 23805908