M. leprae HSP18 suppresses copper (II) mediated ROS generation: Effect of redox stress on its structure and function.
Ascorbic Acid
/ metabolism
Bacterial Proteins
/ genetics
Copper
/ metabolism
Heat-Shock Proteins
/ genetics
Hydrogen Peroxide
/ metabolism
Hydroxyl Radical
/ metabolism
Macrophages
/ microbiology
Molecular Chaperones
/ metabolism
Mycobacterium leprae
/ genetics
Oxidation-Reduction
/ drug effects
Reactive Oxygen Species
/ metabolism
Recombinant Proteins
Tyrosine
/ metabolism
Molecular chaperone
Mycobacterium leprae HSP18
Redox scavenger
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
01 Mar 2020
01 Mar 2020
Historique:
received:
09
08
2019
revised:
16
11
2019
accepted:
24
12
2019
pubmed:
31
12
2019
medline:
15
12
2020
entrez:
30
12
2019
Statut:
ppublish
Résumé
Mycobacterium leprae, causative organism of leprosy, is known to counter redox stress generated by reactive oxygen species (ROS) during its survival inside host macrophages. But, the involvement of any antigenic protein(s) for countering such redox stress is still unknown. Interestingly, M. leprae HSP18, an important antigenic protein that helps in the growth and survival of M. leprae pathogen inside host macrophages, is induced under redox stress. Moreover, HSP18 also interacts with Cu
Identifiants
pubmed: 31883890
pii: S0141-8130(19)36324-X
doi: 10.1016/j.ijbiomac.2019.12.215
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Heat-Shock Proteins
0
Molecular Chaperones
0
Reactive Oxygen Species
0
Recombinant Proteins
0
hsp18 protein, bacteria
0
Hydroxyl Radical
3352-57-6
Tyrosine
42HK56048U
Copper
789U1901C5
Hydrogen Peroxide
BBX060AN9V
Ascorbic Acid
PQ6CK8PD0R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
648-660Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no conflicts of interest with the contents of this article.