Ellagic acid ameliorates lung damage in rats via modulating antioxidant activities, inhibitory effects on inflammatory mediators and apoptosis-inducing activities.
COX-2
Caspase-3
Ellagic acid
Lung damage
Nrf-2
Tnf-α
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
02
08
2019
accepted:
09
12
2019
pubmed:
31
12
2019
medline:
23
4
2020
entrez:
31
12
2019
Statut:
ppublish
Résumé
Phytochemicals is considered one of the most effective and safe alternative therapy against oxidative linked lung diseases. Ellagic acid (EA), an important component of fruits, nuts, and vegetables, are partly responsible for their beneficial health effects against oxidation-related diseases. In the present study, we investigated the ameliorative effect of EA on lung damage induced by carbon tetrachloride (CCl
Identifiants
pubmed: 31885062
doi: 10.1007/s11356-019-07352-8
pii: 10.1007/s11356-019-07352-8
doi:
Substances chimiques
Antioxidants
0
Inflammation Mediators
0
Ellagic Acid
19YRN3ZS9P
Carbon Tetrachloride
CL2T97X0V0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7526-7537Références
Ahmad F, Cowan D, Sun A (1987) Detection of free radical formation in various tissues after acute carbon tetrachloride administration in gerbil. Life Sci 41:2469–2475
Alves CF, Angeli GN, Favarin DC, Andrade EL, Lazo Chica JE, Faccioli LH et al (2013) The effects of proresolution of ellagic acid in an experimental model of allergic airway inflammation. Mediat Inflamm 2013:1–9
Aslan A (2011) The effect of lycopene on the cyclooxygenase (Cox-2), caspase-3,caspase-9, Bax, Bcl-2, p53 protein expression and DNA damage in Rats with azoxhymethane-induced colorectal cancer, PhD Thesis, Firat University Institute of Science, Elazig-Turkey
Aslan A (2015) The effects of different essential fruit juice and their combination on Saccharomyces cerevisiae cell growth. Prog Nutr 17(1):36–40
Aslan A, Can MI (2014) Milk thistle impedes the development of carbontetrachloride-induced liver damage in rats through suppression of bcl-2 and regulating caspase pathway. Life Sci 117(1):13–18
Aslan A, Boydak D, Can MI, Kuloglu T (2015) Nigella sativa improves the carbon tetrachloride-induced lung damage in rats through repression of erk/akt pathway. Bangladesh J Pharmacol 10:654–659
Aslan A, Gok O, Erman O, Kuloglu T (2018) Ellagic acid impedes carbontetrachloride-induced liver damage in rats through suppression of NF-kB, Bcl-2 and regulating Nrf-2 and caspase pathway. Biomed Pharmacother 105:662–669
Azzolina A, Bongiovanni A, Lampiasi N (2003) Substance P induces TNF-α and IL-6 production through NFκB in peritoneal mast cells. Biochim Biophys Acta, Mol Cell Res 1643:75–83
Bargagli E, Olivieri C, Bennett D, Prasse A, Muller-Quernheim J, Rottoli P (2009) Oxidative stress in the pathogenesis of diffuse lung diseases: a review. Respir Med 103:1245–1256
doi: 10.1016/j.rmed.2009.04.014
Beane J, Sebastiani P, Liu G, Brody JS, Lenburg ME, Spira A (2007) Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression. Genome Biol 8(9):1–17
Betsuyaku T, Fuke S, Inomata T, Kaga K, Morikawa T, Odajima N, Adair-Kirk T, Nishimura M (2013) Bronchiolar epithelial catalase is diminished in smokers with mild COPD. Eur Respir J 42:42–53
Biosciences B (2012) Caspase-3 activation-an indicator of apoptosis in image-based assays, Appl Note, 1-4
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424
Casale TB, Costa JJ, Galli SJ (1996) TNF alpha is important in human lung allergic reactions. Am J Respir Cell Mol Biol 15:35–44
Chao PC, Hsu CC, Yin MC (2009) Anti-inflammatory and anti-coagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice. Nutr Metab 6(33):1–8
Christofidou-Solomidou M, Muzykantov VR (2006) Antioxidant strategies in respiratory medicine. Treat Respir Med 5:47–78
Edderkaoui M, Odinokova I, Ohno I, Gukovsky I, Go VLW, Pandol SJ, Gukovskaya AS (2008) Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells. World J Gastroenterol 14:3672–3680
Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82(1):70–77
El-Shitany NA, El-Bastawissy EA, El-desoky K (2014) Ellagic acid protects against carrageenan-induced acute inflammation through inhibition of nuclear factor kappa B, inducible cyclooxygenase and proinflammatory cytokines and enhancement of interleukin-10 via an antioxidant mechanism. Int Immunopharmacol 19:290–299
Fang YZ, Yang S, Wu G (2002) Free radicals, antioxidants, and nutrition. Nutrition 18:872–879
Favarin DC, Teixeira MM, Andrade EL, Alves CF, Lazo Chica JE, Artério Sorgi C et al (2013) Anti-inflammatory effects of ellagic acid on acute lung injury induced by acid in mice. Mediat Inflamm 2013:1–13
Forman HJ, Zhang H, Rinna A (2009) Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Asp Med 30:1–12
Fridovich I, Freeman B (1986) Antioxidant defenses in the lung. Annu Rev Physiol 48:693–702
Ganie SA, Haq E, Hamid A, Qurishi Y, Mahmood Z, Zargar BA et al (2011a) Carbon tetrachloride induced kidney and lung tissue damages and antioxidant activities of the aqueous rhizome extract of Podophyllum hexandrum. BMC Complement Altern Med 11(17):1–10
Ganie SA, Haq E, Masood A, Hamid A, Zargar MA (2011b) Antioxidant and protective effect of ethyl acetate extract of Podophyllum hexandrum rhizome on carbon tetrachloride induced rat liver injury. Evid Based Complement Alternat Med 2011:1–12
Girish C, Koner BC, Jayanthi S, Ramachandra Rao K, Rajesh B, Pradhan SC (2009) Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fundam Clin Pharmacol 23:735–745
Gould NS, Min E, Gauthier S, Martin RJ, Day BJ (2011) Lung glutathione adaptive responses to cigarette smoke exposure. Respir Res 12(133):1–9
Grossi MR, Berni A, Pepe G, Filippi S, Meschini R, Papeschi C, Natarajan AT, Palitti F (2014) Evaluation of the effects of ellagic acid (EA) on 7, 12-dimethylbenz (α) anthracene (DMBA) induced micronuclei in mammalian cells in vitro and in vivo. Toxicol Lett 224:240–245
Gu L, Deng W-s, Liu Y, Jiang C-h, Sun L-c, Sun X-f et al (2014) Ellagic acid protects lipopolysaccharide/D-galactosamine-induced acute hepatic injury in mice. Int Immunopharmacol 22:341–345
Gul M, Aliosmanoglu I, Uslukaya O, Firat U, Yüksel H, Gümüs M, Ulger BV (2013) The protective effect of ellagic acid on lung damage caused by experimental obstructive jaundice model. Acta Chir Belg 113:285–289
Gutteridge J (1995) Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem 41:1819–1828
Halliwell B, Guttridge JM (2015) Free radicals in biology and medicine, 6th edn. Oxford, Oxford University Press
Han DH, Lee MJ, Kim JH (2006) Antioxidant and apoptosis-inducing activities of ellagic acid. Anticancer Res 26:3601–3606
Hashemi Goradel N, Najafi M, Salehi E, Farhood B, Mortezaee K (2019) Cyclooxygenase-2 in cancer: a review. J Cell Physiol 234:5683–5699
Henson PM, Tuder RM (2008) Apoptosis in the lung: induction, clearance and detection. Am J Physiol Lung Cell Mol Physiol 294:L601–L611
Hseu YC, Chou CW, Kumar KS, Fu KT, Wang HM, Hsu LS, Kuo YH, Wu CR, Chen SC, Yang HL (2012) Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes. Food Chem Toxicol 50:1245–1255
Kawanishi S, Ohnishi S, Ma N, Hiraku Y, Oikawa S, Murata M (2016) Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells. Genes Environ 38(26):1–12
Khan RA, Khan MR, Sahreen S (2012) Protective effect of Sonchus asper extracts against experimentally induced lung injuries in rats: a novel study. Exp Toxicol Pathol 64:725–731
Khan RA, Alkreathy HM, Saboorshah A, Ahmed M, Khan S (2016) Protective effects of Trifolium alexandrinum L. against lung injury induced by environmental toxin CCl4 in experimental rats. Food Nutr Res 60:1–5
Kidd PM (1997) Glutathione: systematic protectant against oxidative and free radical damage. Altern Med Rev 2:155–176
Kim YS, Zerin T, Song HY (2013) Antioxidant action of ellagic acid ameliorates paraquat-induced A549 cytotoxicity. Biol Pharm Bull 36:609–615
Kode A, Rajendrasozhan S, Caito S, Yang S-R, Megson IL, Rahman I (2008) Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 294:L478–L488
Krysan K, Reckamp KL, Sharma S, Dubinett SM (2006) The potential and rationale for COX-2 inhibitors in lung cancer. Anti Cancer Agents Med Chem 6:209–220
Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680–685
Lee IT, Yang CM (2012) Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases. Biochem Pharmacol 84:581–590
Lobo V, Patil A, Phatak A, Chandra N (2010) Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev 4:118–126
Lomaestro BM, Malone M (1995) Glutathione in health and disease: pharmacotherapeutic issues. Ann Pharmacother 29:1263–1273
Lu K-H, Weng C-Y, Chen W-C, Sheen L-Y (2017) Ginseng essence, a medicinal and edible herbal formulation, ameliorates carbon tetrachloride-induced oxidative stress and liver injury in rats. J Ginseng Res 41:316–325
Luck H (1963) Catalase. Methods of enzymatic analysis/H.–U. Bergmeyer ed. Verlag Chemie, GmbH, Academic Press, New York. pp 885–894
Majid S, Khanduja KL, Gandhi RK, Kapur S, Sharma RR (1991) Influence of ellagic acid on antioxidant defense system and lipid peroxidation in mice. Biochem Pharmacol 42:1441–1445
Makena PS, Chung K-T (2007) Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity. Food Chem Toxicol 45:1899–1909
Makni M, Chtourou Y, Barkallah M, Fetoui H (2012) Protective effect of vanillin against carbon tetrachloride (CCl4)-induced oxidative brain injury in rats. Toxicol Ind Health 28:655–662
Mantell LL, Kazzaz JA, Xu J, Palaia TA, Piedboeuf B, Hall S, Rhodes GC, Niu G, Fein AF, Horowitz S (1997) Unscheduled apoptosis during acute inflammatory lung injury. Cell Death Differ 4:600–607
Mathers CD, Loncar D (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3(11):2011–2030
Mukhopadhyay S, Hoidal JR, Mukherjee TK (2006) Role of TNFα in pulmonary pathophysiology. Respir Res 7(125):1–9
Murata M, Thanan R, Ma N, Kawanishi S (2012) Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis. Biomed Res Int 2012:1–11
Nagata S (2018) Apoptosis and clearance of apoptotic cells. Annu Rev Immunol 36:489–517
Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–358
Pari L, Sivasankari R (2008) Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats. Fundam Clin Pharmacol 22:395–401
Park HS, Kim SR, Lee YC (2009) Impact of oxidative stress on lung diseases. Respirology 14:27–38
Pavlica S, Gebhardt R (2005) Protective effects of ellagic and chlorogenic acids against oxidative stress in PC12 cells. Free Radic Res 39:1377–1390
Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V et al (2017) Oxidative stress: harms and benefits for human health. Oxidative Med Cell Longev 2017:1–13
Polunovsky VA, Chen B, Henke C, Snover D, Wendt C, Ingbar DH, Bitterman PB (1993) Role of mesenchymal cell death in lung remodeling after injury. J Clin Invest 92:388–397
Priyadarsini KI, Khopde SM, Kumar SS, Mohan H (2002) Free radical studies of ellagic acid, a natural phenolic antioxidant. J Agric Food Chem 50:2200–2206
Rahman I, Biswas SK, Kode A (2006) Oxidant and antioxidant balance in the airways and airway diseases. Eur J Pharmacol 533:222–239
Ritesh K, Suganya A, Dileepkumar H, Rajashekar Y, Shivanandappa T (2015) A single acute hepatotoxic dose of CCl4 causes oxidative stress in the rat brain. Toxicol Rep 2:891–895
Rogers LK, Cismowski MJ (2018) Oxidative stress in the lung–the essential paradox. Curr Opin Toxicol 7:37–43
Saba SK, Parvez S, Chaudhari B, Ahmad B, Anjum F, Anjum S, Raisuddin S (2013) Ellagic acid attenuates bleomycin and cyclophosphamide-induced pulmonary toxicity in Wistar rats. Food Chem Toxicol 58:210–219
Sandberg M, Patil J, D’Angelo B, Weber SG, Mallard C (2014) NRF2-regulation in brain health and disease: implication of cerebral inflammation. Neuropharmacology 79:298–306
Sandler AB, Dubinett SM (2004) COX-2 inhibition and lung cancer. Semin Oncol 45–52
Simon RH, DeHart PD, Nadeau DM (1989) Resistance of rat pulmonary alveolar epithelial cells to neutrophil- and oxidant-induced injury. Am J Respir Cell Mol Biol 1:221–229
Sobolewski C, Cerella C, Dicato M, Ghibelli L, Diederich M (2010) The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. Int J Cell Biol 2010
Sudheer AR, Muthukumaran S, Devipriya N, Menon VP (2007) Ellagic acid, a natural polyphenol protects rat peripheral blood lymphocytes against nicotine-induced cellular and DNA damage in vitro: with the comparison of N-acetylcysteine. Toxicology 230:11–21
Surh Y-J, Kundu JK, Na H-K (2008) Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med 74:1526–1539
Tanigaki R, Takahashi R, Nguyen MTT, Nguyen NT, Do TVN, Nguyen HX, Kataoka T (2019) 4-Hydroxypanduratin A and isopanduratin A inhibit tumor necrosis factor α-stimulated gene expression and the nuclear factor κB-dependent signaling pathway in human lung adenocarcinoma A549 cells. Biol Pharm Bull 42:26–33
Tekeli IO, Atessahin A, Sakin F, Aslan A, Ceribasi S, Yipel M (2019) Protective effects of conventional and colon targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats. Inflammopharmacology 27(2):313–322
Uhal BD, Joshi I, True AL, Mundle S, Raza A, Pardo A et al (1995) Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro. Am J Physiol Lung Cell Mol Physiol 269:L819–L828
Umesalma S, Sudhandiran G (2010) Differential inhibitory effects of the polyphenol ellagic acid on inflammatory mediators NF-κB, iNOS, COX-2, TNF-α, and IL-6 in 1, 2-dimethylhydrazine-induced rat colon carcinogenesis. Basic Clin Pharmacol Toxicol 107:650–655
Umesalma S, Nagendraprabhu P, Sudhandiran G (2015) Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells. Mol Cell Biochem 399:303–313
Valavanidis A, Vlachogianni T, Fiotakis K, Loridas S (2013) Pulmonary oxidative stress, inflammation and cancer: respirable particulate matter, fibrous dusts and ozone as major causes of lung carcinogenesis through reactive oxygen species mechanisms. Int J Environ Res 10:3886–3907
Vattem D, Shetty K (2005) Biological functionality of ellagic acid: a review. J Food Biochem 29:234–266
Wang J, Liu Y-T, Xiao L, Zhu L, Wang Q, Yan T (2014) Anti-inflammatory effects of apigenin in lipopolysaccharide-induced inflammatory in acute lung injury by suppressing COX-2 and NF-kB pathway. Inflammation 37:2085–2090
Weber LW, Boll M, Stampfl A (2003) Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 33:105–136
Yadav AK, Bracher A, Doran SF, Leustik M, Squadrito GL, Postlethwait EM, Matalon S (2010) Mechanisms and modification of chlorine-induced lung injury in animals. Proc Am Thorac Soc 7:278–283
Yao R, Rioux N, Castonguay A, You M (2000) Inhibition of COX-2 and induction of apoptosis: two determinants of nonsteroidal anti-inflammatory drugs’ chemopreventive efficacies in mouse lung tumorigenesis. Exp Lung Res 26:731–742
Yigit M (2015) Effects of astaxanthin on antioxidant parameters (GSH, GSH-Px, MDA), Ca2+ signaling and apoptosis levels in ARPE-19 cells on cigarette smoke-related hydrokuinon induced oxidative stress model. Thesis in Medicine, Süleyman Demirel University Faculty of Medicine, Isparta-Turkey
Yüce A, Ateşşahin A, Çeribaşı AO, Aksakal M (2007) Ellagic acid prevents cisplatin-induced oxidative stress in liver and heart tissue of rats. Basic Clin Pharmacol Toxicol 101:345–349
Zhang K, Gharaee-Kermani M, McGarry B, Remick D, Phan SH (1997) TNF-alpha-mediated lung cytokine networking and eosinophil recruitment in pulmonary fibrosis. J Immunol 158:954–959
Zhang X, Song K, Xiong H, Li H, Chu X, Deng X (2009) Protective effect of florfenicol on acute lung injury induced by lipopolysaccharide in mice. Int Immunopharmacol 9:1525–1529
Zhao H, Eguchi S, Alam A, Ma D (2017) The role of nuclear factor-erythroid 2 related factor 2 (Nrf-2) in the protection against lung injury. Am J Physiol Lung Cell Mol Physiol 312:L155–L162
Zhou E, Fu Y, We Z, Yang Z (2014) Inhibition of allergic airway inflammation through the blockage of NF-κB activation by ellagic acid in an ovalbumin-induced mouse asthma model. Food Funct 5(9):2106–2112
Zhou B, Li Q, Wang J, Chen P, Jiang S (2019) Ellagic acid attenuates streptozocin induced diabetic nephropathy via the regulation of oxidative stress and inflammatory signaling. Food Chem Toxicol 123:16–27