Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement.

Cell Cycle Proteins / chemistry Chromatin Assembly and Disassembly / genetics Chromosomal Proteins, Non-Histone / chemistry Cryoelectron Microscopy DNA Repair / genetics DNA, Fungal / chemistry DNA-Binding Proteins / chemistry Multiprotein Complexes / chemistry Nucleosomes / chemistry Saccharomyces cerevisiae / chemistry Saccharomyces cerevisiae Proteins / chemistry Transcription Factors / chemistry
S. cerevisiae chromatin chromatin remodeling cryo-EM molecular biophysics structural biology transcription

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
30 12 2019
Historique:
received: 16 12 2019
accepted: 23 12 2019
pubmed: 31 12 2019
medline: 13 6 2020
entrez: 31 12 2019
Statut: epublish

Résumé

Eukaryotic DNA is packaged into nucleosome arrays, which are repositioned by chromatin remodeling complexes to control DNA accessibility. The

Identifiants

DOI: 10.7554/eLife.54449 PMID: 31886770 PMC: PMC6959994
pubmed: 31886770
doi: 10.7554/eLife.54449
pii: 54449
pmc: PMC6959994
doi:
pii:

Substances chimiques

Cell Cycle Proteins 0
Chromosomal Proteins, Non-Histone 0
DNA, Fungal 0
DNA-Binding Proteins 0
Multiprotein Complexes 0
NPL6 protein, S cerevisiae 0
Nucleosomes 0
RSC complex, S cerevisiae 0
SWI-SNF-B chromatin-remodeling complex 0
Saccharomyces cerevisiae Proteins 0
Sfh1 protein, S cerevisiae 0
Transcription Factors 0

Banques de données

PDB
['6V8O', '6V92']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM127018
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35-GM127018
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01-HL133678
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01-GM63072
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01-GM110064
Pays : United States
Organisme : NIH HHS
ID : U24GM129547
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01- GM110064
Pays : United States

Informations de copyright

© 2019, Patel et al.

Déclaration de conflit d'intérêts

AP, CM, BG, JL, SZ, JR, EN No competing interests declared

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Auteurs

Avinash B Patel (AB)

Biophysics Graduate Group, University of California, Berkeley, Berkeley, United States.
Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States.
ORCID: 0000-0001-9140-8375

Camille M Moore (CM)

Molecular and Cell Biology Department, University of California, Berkeley, Berkeley, United States.

Basil J Greber (BJ)

Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States.
California Institute for Quantitative Biology (QB3), University of California, Berkeley, Berkeley, United States.
ORCID: 0000-0001-9379-7159

Jie Luo (J)

The Institute for Systems Biology, Seattle, United States.

Stefan A Zukin (SA)

Chemistry Department, University of California, Berkeley, Berkeley, United States.

Jeff Ranish (J)

The Institute for Systems Biology, Seattle, United States.

Eva Nogales (E)

Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States.
Molecular and Cell Biology Department, University of California, Berkeley, Berkeley, United States.
California Institute for Quantitative Biology (QB3), University of California, Berkeley, Berkeley, United States.
Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, United States.
ORCID: 0000-0001-9816-3681

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Architecture of the chromatin remodeler RSC...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Assemblage et désassemblage de la chromatine › Architecture of the chromatin remodeler RSC...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines chromosomiques nonhistones › Architecture of the chromatin remodeler RSC...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Architecture of the chromatin remodeler RSC...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › Architecture of the chromatin remodeler RSC...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN fongique › Architecture of the chromatin remodeler RSC...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Architecture of the chromatin remodeler RSC...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Architecture of the chromatin remodeler RSC...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Nucléosomes › Architecture of the chromatin remodeler RSC...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Architecture of the chromatin remodeler RSC...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Architecture of the chromatin remodeler RSC...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Architecture of the chromatin remodeler RSC...