Immunosuppressive withanolides from the flower of Datura metel L.
Antiproliferative
Datura metel L.
Immunosupressive
Withanolide
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
15
11
2019
revised:
21
12
2019
accepted:
27
12
2019
pubmed:
31
12
2019
medline:
18
11
2020
entrez:
31
12
2019
Statut:
ppublish
Résumé
Thirteen new withanolide aglycones, baimantuoluolines L-X (1-13) and one new withanolide glycoside, baimantuoluoside J (14) were isolated from Datura metel L. flowers. The structures of the new compounds were elucidated by the detailed analysis of 1D and 2D NMR techniques and mass spectrometry, together with the closely related literatures. Meanwhile, all isolated compounds were evaluated for their immunosuppressive activities against mice splenocyte proliferation and antiproliferative activities against human gastric adenocarcinoma cells (SGC-7901), human hepatoma (HepG2), and human breast cancer (MCF-7) in vitro. It was found that compounds 1-14 showed obvious immunosupressive effects and some of them have moderated antiproliferative activities.
Identifiants
pubmed: 31887326
pii: S0367-326X(19)32247-6
doi: 10.1016/j.fitote.2019.104468
pii:
doi:
Substances chimiques
Immunosuppressive Agents
0
Withanolides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104468Informations de copyright
Copyright © 2019. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no competing financial interest.