Proteins, peptides and peptidomimetics as active agents in implant surface functionalization.
Implants
Osseointegration
Osteointegration
Peptides
Peptidomimetics
Proteins
Surface functionalization
Journal
Advances in colloid and interface science
ISSN: 1873-3727
Titre abrégé: Adv Colloid Interface Sci
Pays: Netherlands
ID NLM: 8706645
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
15
10
2019
revised:
09
12
2019
accepted:
09
12
2019
pubmed:
31
12
2019
medline:
22
9
2020
entrez:
31
12
2019
Statut:
ppublish
Résumé
The recent impact of implants on improving the human life quality has been enormous. During the past two decades we witnessed major advancements in both material and structural development of implants. They were driven mainly by the increasing patients' demand and the need to address the major issues that come along with the initially underestimated complexity of the bone-implant interface. While both, the materials and design of implants reached a certain, balanced state, recent years brought a shift in focus towards the bone-implant interface as the weakest link in the increasing implant long-term usability. As a result, several approaches were developed. They aimed at influencing and enhancing the implant osseointegration and its proper behavior when under load and stress. With this review, we would like to discuss the recent advancements in the field of implant surface modifications, emphasizing the importance of chemical methods, focusing on proteins, peptides and peptidomimetics as promising agents for titanium surface coatings.
Identifiants
pubmed: 31887572
pii: S0001-8686(19)30371-9
doi: 10.1016/j.cis.2019.102083
pii:
doi:
Substances chimiques
Peptides
0
Peptidomimetics
0
Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102083Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.