Oral administration of EP4-selective agonist KAG-308 suppresses mouse knee osteoarthritis development through reduction of chondrocyte hypertrophy and TNF secretion.
Administration, Oral
Animals
Anti-Inflammatory Agents
/ administration & dosage
Biopsy
Cartilage
/ drug effects
Chondrocytes
/ drug effects
Cyclic AMP
Disease Models, Animal
Epoprostenol
/ administration & dosage
Humans
Mice
Osteoarthritis, Knee
/ drug therapy
Protein Transport
Receptors, Prostaglandin E, EP4 Subtype
/ antagonists & inhibitors
Signal Transduction
Synovial Membrane
/ drug effects
Tumor Necrosis Factor-alpha
/ biosynthesis
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 12 2019
30 12 2019
Historique:
received:
27
08
2019
accepted:
17
12
2019
entrez:
1
1
2020
pubmed:
1
1
2020
medline:
12
11
2020
Statut:
epublish
Résumé
Osteoarthritis (OA) is one of the world's most common degenerative diseases, but there is no disease-modifying treatment available. Previous studies have shown that prostaglandin E2 (PGE
Identifiants
pubmed: 31889132
doi: 10.1038/s41598-019-56861-6
pii: 10.1038/s41598-019-56861-6
pmc: PMC6937271
doi:
Substances chimiques
Anti-Inflammatory Agents
0
KAG-308
0
Receptors, Prostaglandin E, EP4 Subtype
0
Tumor Necrosis Factor-alpha
0
Epoprostenol
DCR9Z582X0
Cyclic AMP
E0399OZS9N
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20329Références
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