Impact on blood safety of the last arboviruses outbreaks in French Polynesia (2012-2018).
Arboviruses
/ drug effects
Blood Donors
/ supply & distribution
Blood Safety
/ methods
Blood-Borne Pathogens
/ drug effects
Chikungunya Fever
/ blood
Dengue
/ blood
Disease Outbreaks
Donor Selection
/ statistics & numerical data
Furocoumarins
/ pharmacology
Humans
Photosensitizing Agents
/ pharmacology
Polynesia
/ epidemiology
RNA, Viral
/ blood
Seroepidemiologic Studies
Viremia
/ blood
Zika Virus Infection
/ blood
Arbovirus
Arboviruses
Atténuation des pathogènes
Blood donors
Donneurs de sang
Dépistage génomique viral
French Polynesia
Nucleic acid testing
Pathogen reduction
Polynésie française
Journal
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
ISSN: 1953-8022
Titre abrégé: Transfus Clin Biol
Pays: France
ID NLM: 9423846
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
16
10
2019
accepted:
03
12
2019
pubmed:
1
1
2020
medline:
5
1
2021
entrez:
1
1
2020
Statut:
ppublish
Résumé
Several successive arbovirus outbreaks have affected French Polynesia (FP) in the recent past years due to different dengue serotypes (DENV) present for several decades, Zika (ZIKV) (2013-2014) and chikungunya (CHIKV) (2014-2015) viruses with a potential impact on blood safety and blood supply due to the geographical isolation of these islands. This study reports an assessment of the impact of these outbreaks on blood products supply and infectious safety in FP and discuss the effectiveness of implemented preventive measures. To ensure the infectious safety of blood products during outbreaks, several measures have successively been introduced as the selection of donors suspected of infection, the nucleic acid testing (NAT) and the pathogen reduction of platelets and plasmas. The donor deferral rate increased by 6% between 2012 and 2014 without changes in the number of collected donations. NAT excluded five blood donations reactive for DENV RNA, 42 for ZIKV and 34 for CHIKV. As Zika screening could not been implemented before the third month of the outbreak, 36 blood products from ZIKV-infected donors were transfused to 26 recipients. However, no transfusion-transmitted arbovirus has been reported. The last past arboviruses outbreaks did not have a significant impact on blood supply in FP. The measures introduced to prevent arbovirus transmission by transfusion were able to maintain infectious safety for all blood products without impairing self-sufficiency.
Sections du résumé
BACKGROUND
BACKGROUND
Several successive arbovirus outbreaks have affected French Polynesia (FP) in the recent past years due to different dengue serotypes (DENV) present for several decades, Zika (ZIKV) (2013-2014) and chikungunya (CHIKV) (2014-2015) viruses with a potential impact on blood safety and blood supply due to the geographical isolation of these islands. This study reports an assessment of the impact of these outbreaks on blood products supply and infectious safety in FP and discuss the effectiveness of implemented preventive measures.
METHODS
METHODS
To ensure the infectious safety of blood products during outbreaks, several measures have successively been introduced as the selection of donors suspected of infection, the nucleic acid testing (NAT) and the pathogen reduction of platelets and plasmas.
RESULTS
RESULTS
The donor deferral rate increased by 6% between 2012 and 2014 without changes in the number of collected donations. NAT excluded five blood donations reactive for DENV RNA, 42 for ZIKV and 34 for CHIKV. As Zika screening could not been implemented before the third month of the outbreak, 36 blood products from ZIKV-infected donors were transfused to 26 recipients. However, no transfusion-transmitted arbovirus has been reported.
CONCLUSION
CONCLUSIONS
The last past arboviruses outbreaks did not have a significant impact on blood supply in FP. The measures introduced to prevent arbovirus transmission by transfusion were able to maintain infectious safety for all blood products without impairing self-sufficiency.
Identifiants
pubmed: 31889619
pii: S1246-7820(19)30464-1
doi: 10.1016/j.tracli.2019.12.001
pii:
doi:
Substances chimiques
Furocoumarins
0
Photosensitizing Agents
0
RNA, Viral
0
amotosalen
K1LDZ0VBC0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4-9Informations de copyright
Copyright © 2019 Société française de transfusion sanguine (SFTS). Published by Elsevier Masson SAS. All rights reserved.