Seven-day overfeeding enhances adipose tissue dietary fatty acid storage and decreases myocardial and skeletal muscle dietary fatty acid partitioning in healthy subjects.
Adipose Tissue
/ metabolism
Adult
Body Composition
Cross-Over Studies
Dietary Carbohydrates
/ pharmacology
Dietary Fats
/ pharmacology
Fatty Acids
/ metabolism
Female
Healthy Volunteers
Humans
Hyperphagia
/ metabolism
Insulin Resistance
Male
Middle Aged
Muscle, Skeletal
/ diagnostic imaging
Myocardium
/ metabolism
Positron-Emission Tomography
Ventricular Function, Left
/ drug effects
dietary fatty acids
healthy subjects
high calorie
high-fat diet
positron emission tomography
postprandial metabolism
Journal
American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226
Informations de publication
Date de publication:
01 02 2020
01 02 2020
Historique:
pubmed:
1
1
2020
medline:
6
5
2020
entrez:
1
1
2020
Statut:
ppublish
Résumé
Increased myocardial partitioning of dietary fatty acids (DFA) and decreased left ventricular (LV) function is associated with insulin resistance in prediabetes. We hypothesized that enhanced myocardial DFA partitioning and reduced LV function might be induced concomitantly with reduced insulin sensitivity upon a 7-day hypercaloric (+50% in caloric intake), high-saturated fat (~11%energy), and simple carbohydrates (~54%energy) diet (HIGHCAL) versus an isocaloric diet (ISOCAL) with a moderate amount of saturated fat (~8%energy) and carbohydrates (~50%energy). Thirteen healthy subjects (7 men/6 women) underwent HIGHCAL versus ISOCAL in a randomized crossover design, with organ-specific DFA partitioning and LV function measured using the oral 14(
Identifiants
pubmed: 31891539
doi: 10.1152/ajpendo.00474.2019
doi:
Substances chimiques
Dietary Carbohydrates
0
Dietary Fats
0
Fatty Acids
0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
E286-E296Subventions
Organisme : CIHR
ID : MOP53094
Pays : Canada