Kainic acid-induced status epilepticus decreases mGlu
Animals
Disease Models, Animal
Down-Regulation
Excitatory Amino Acid Agonists
/ administration & dosage
Glial Fibrillary Acidic Protein
/ metabolism
Hippocampus
/ drug effects
Homer Scaffolding Proteins
/ metabolism
Kainic Acid
/ administration & dosage
Male
RNA, Messenger
/ metabolism
Rats, Sprague-Dawley
Receptor, Metabotropic Glutamate 5
/ metabolism
Status Epilepticus
/ chemically induced
Epileptogenesis
Hippocampus
Homer1
Kainic acid
Temporal lobe epilepsy
mGlu(5) receptor
Journal
Brain research
ISSN: 1872-6240
Titre abrégé: Brain Res
Pays: Netherlands
ID NLM: 0045503
Informations de publication
Date de publication:
01 03 2020
01 03 2020
Historique:
received:
24
07
2019
revised:
05
12
2019
accepted:
27
12
2019
pubmed:
1
1
2020
medline:
8
6
2021
entrez:
1
1
2020
Statut:
ppublish
Résumé
Globally, over 50 million people are affected by epilepsy, which is characterized by the occurrence of spontaneous recurrent seizures. Almost one-third of the patients show resistance to current anti-epileptic drugs, making the exploration of new molecular targets necessary. An interesting target may be Homer1, due to its diverse roles in epileptogenesis and synaptic plasticity. Indeed, Homer1 regulates group I metabotropic glutamate (mGlu) receptors (i.e. mGlu
Identifiants
pubmed: 31891692
pii: S0006-8993(19)30694-8
doi: 10.1016/j.brainres.2019.146640
pii:
doi:
Substances chimiques
Excitatory Amino Acid Agonists
0
GFAP protein, rat
0
Glial Fibrillary Acidic Protein
0
Grm5 protein, rat
0
Homer Scaffolding Proteins
0
Homer1 protein, rat
0
RNA, Messenger
0
Receptor, Metabotropic Glutamate 5
0
Kainic Acid
SIV03811UC
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
146640Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.