A catalytic bioscavenger with improved stability and reduced susceptibility to oxidation for treatment of acute poisoning with neurotoxic organophosphorus compounds.
Antidotes
/ metabolism
Bacterial Proteins
/ genetics
Caulobacteraceae
/ enzymology
Drug Stability
Enzyme Stability
Hot Temperature
Mutation
Nerve Agents
/ poisoning
Organophosphate Poisoning
/ drug therapy
Organophosphorus Compounds
/ toxicity
Organothiophosphorus Compounds
/ poisoning
Oxidation-Reduction
Phosphoric Triester Hydrolases
/ genetics
Protein Denaturation
Recombinant Proteins
/ pharmacology
Sarin
/ poisoning
Soman
/ poisoning
Bioscavenger
Enzyme engineering
Organophosphate hydrolase
Organophosphorus compound
Phosphotriesterase
Protein oxidation
Journal
Toxicology letters
ISSN: 1879-3169
Titre abrégé: Toxicol Lett
Pays: Netherlands
ID NLM: 7709027
Informations de publication
Date de publication:
15 Mar 2020
15 Mar 2020
Historique:
received:
22
09
2019
revised:
23
12
2019
accepted:
25
12
2019
pubmed:
1
1
2020
medline:
28
1
2020
entrez:
1
1
2020
Statut:
ppublish
Résumé
Organophosphorus (OP)
Identifiants
pubmed: 31891759
pii: S0378-4274(19)30424-2
doi: 10.1016/j.toxlet.2019.12.030
pii:
doi:
Substances chimiques
Antidotes
0
Bacterial Proteins
0
Nerve Agents
0
Organophosphorus Compounds
0
Organothiophosphorus Compounds
0
Recombinant Proteins
0
Soman
96-64-0
VX
9A4381183B
Sarin
B4XG72QGFM
Phosphoric Triester Hydrolases
EC 3.1.8.-
S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate
LG34LSI9IU
cyclohexyl methylphosphonofluoridate
VM36F9N236
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
138-145Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.