Post-sepsis syndrome - an evolving entity that afflicts survivors of sepsis.
HMGB1
Post-sepsis syndrome
Sepsis sequelae
Sepsis survivors
Journal
Molecular medicine (Cambridge, Mass.)
ISSN: 1528-3658
Titre abrégé: Mol Med
Pays: England
ID NLM: 9501023
Informations de publication
Date de publication:
31 12 2019
31 12 2019
Historique:
received:
01
08
2019
accepted:
20
12
2019
entrez:
2
1
2020
pubmed:
2
1
2020
medline:
19
6
2020
Statut:
epublish
Résumé
The sequelae of sepsis were once thought to be independent of sepsis itself and assumed to be either comorbid to sick patients or complications of critical illness. Recent studies have reported consistent patterns of functional disabilities in sepsis survivors that can last from months to years after symptoms of active sepsis had resolved. BODY: Post-sepsis syndrome is an emerging pathological entity that has garnered significant interest amongst clinicians and researchers over the last two decades. It is marked by a significantly increased risk of death and a poor health-related quality of life associated with a constellation of long-term effects that persist following the patient's bout with sepsis. These include neurocognitive impairment, functional disability, psychological deficits, and worsening medical conditions. This "post-sepsis syndrome" has been the subject of active preclinical and clinical research providing new mechanistic insights and approaches linked to survivor well-being. Here we review important aspects of these research efforts and goals of care for patients who survive sepsis.
Sections du résumé
BACKGROUND
The sequelae of sepsis were once thought to be independent of sepsis itself and assumed to be either comorbid to sick patients or complications of critical illness. Recent studies have reported consistent patterns of functional disabilities in sepsis survivors that can last from months to years after symptoms of active sepsis had resolved. BODY: Post-sepsis syndrome is an emerging pathological entity that has garnered significant interest amongst clinicians and researchers over the last two decades. It is marked by a significantly increased risk of death and a poor health-related quality of life associated with a constellation of long-term effects that persist following the patient's bout with sepsis. These include neurocognitive impairment, functional disability, psychological deficits, and worsening medical conditions.
CONCLUSION
This "post-sepsis syndrome" has been the subject of active preclinical and clinical research providing new mechanistic insights and approaches linked to survivor well-being. Here we review important aspects of these research efforts and goals of care for patients who survive sepsis.
Identifiants
pubmed: 31892321
doi: 10.1186/s10020-019-0132-z
pii: 10.1186/s10020-019-0132-z
pmc: PMC6938630
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
6Références
NPJ Biofilms Microbiomes. 2017 Nov 13;3:31
pubmed: 29152323
Brain Pathol. 2004 Jan;14(1):21-33
pubmed: 14997934
Neurotherapeutics. 2010 Oct;7(4):366-77
pubmed: 20880501
NCHS Data Brief. 2014 Dec;(172):1-8
pubmed: 25470183
Am J Geriatr Psychiatry. 2013 Sep;21(9):887-97
pubmed: 23567391
Lancet. 2003 Nov 29;362(9398):1799-805
pubmed: 14654318
Curr Infect Dis Rep. 2016 Nov;18(11):37
pubmed: 27709504
Anaesthesia. 2005 Nov;60(11):1085-92
pubmed: 16229693
JAMA. 2010 Oct 27;304(16):1787-94
pubmed: 20978258
Circulation. 1998 May 12;97(18):1837-47
pubmed: 9603539
Mol Med. 2008 Jul-Aug;14(7-8):476-84
pubmed: 18431461
Mol Med. 2012 Sep 07;18:930-7
pubmed: 22634723
Eur Arch Otorhinolaryngol. 2014 Nov;271(11):3085-93
pubmed: 24970291
Lancet Respir Med. 2015 Jan;3(1):61-9
pubmed: 25434614
PLoS One. 2011;6(8):e22847
pubmed: 21853050
Crit Care Med. 2016 Sep;44(9):1744-53
pubmed: 27153046
Crit Care Clin. 2009 Jan;25(1):83-101, viii
pubmed: 19268796
Crit Care. 2016 Oct 29;20(1):354
pubmed: 27793165
J Anxiety Disord. 2013 Jan;27(1):33-46
pubmed: 23247200
Am J Respir Crit Care Med. 2014 May 1;189(9):1065-74
pubmed: 24456535
Nat Rev Immunol. 2013 Dec;13(12):862-74
pubmed: 24232462
Thorax. 2016 Oct;71(10):881-90
pubmed: 27220357
J Gen Intern Med. 2001 Nov;16(11):770-8
pubmed: 11722692
JAMA. 2015 Jan 20;313(3):264-74
pubmed: 25602997
Crit Care Med. 1998 Apr;26(4):651-9
pubmed: 9559601
Intensive Care Med Exp. 2015 Dec;3(1):30
pubmed: 26515197
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3666-70
pubmed: 1103152
Crit Care Med. 2013 Jan;41(1):263-306
pubmed: 23269131
Crit Care Med. 2001 Jul;29(7):1303-10
pubmed: 11445675
Crit Care Med. 2010 May;38(5):1276-83
pubmed: 20308885
Lancet. 2009 May 30;373(9678):1874-82
pubmed: 19446324
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
Nat Neurosci. 2017 Feb;20(2):156-166
pubmed: 28092663
Gut Microbes. 2011 May-Jun;2(3):145-58
pubmed: 21804357
Lancet. 2013 Mar 2;381(9868):774-5
pubmed: 23472921
Diabetes Care. 2010 Mar;33(3):639-44
pubmed: 20032274
Crit Care Med. 2015 May;43(5):1121-9
pubmed: 25654178
Alzheimers Dement. 2008 Sep;4(5):316-23
pubmed: 18790458
JAMA. 2018 Jan 2;319(1):62-75
pubmed: 29297082
Clin Infect Dis. 2005 Nov 15;41 Suppl 7:S490-7
pubmed: 16237652
Semin Dial. 2009 Jul-Aug;22(4):340-5
pubmed: 19708978
Crit Care. 2011;15(3):R131
pubmed: 21612615
Curr Opin Microbiol. 2014 Feb;17:67-74
pubmed: 24581695
Am J Respir Crit Care Med. 2008 Jun 1;177(11):1242-7
pubmed: 18369199
Lancet Infect Dis. 2010 Feb;10(2):83-92
pubmed: 20113977
Crit Care Med. 2010 Jul;38(7):1513-20
pubmed: 20473145
JAMA. 2014 Mar 19;311(11):1133-42
pubmed: 24643603
Neurology. 2014 Aug 5;83(6):486-93
pubmed: 24991031
Crit Care Med. 2013 Jan;41(1):69-75
pubmed: 23222259
Psychol Med. 1996 Nov;26(6):1271-6
pubmed: 8931173
Intensive Care Med. 2004 Mar;30(3):450-5
pubmed: 12961065
Crit Rev Clin Lab Sci. 2013 Jan-Feb;50(1):23-36
pubmed: 23480440
J Gerontol A Biol Sci Med Sci. 2001 Oct;56 Spec No 2:13-22
pubmed: 11730234
Lancet. 2010 Oct 16;376(9749):1339-46
pubmed: 20934212
Annu Rev Public Health. 2013;34:119-38
pubmed: 23514317
Front Immunol. 2019 Apr 02;10:585
pubmed: 31024522
Nurs Crit Care. 2013 Jan-Feb;18(1):32-42
pubmed: 23289555
JAMA. 2017 Oct 3;318(13):1241-1249
pubmed: 28903154
Brain Inj. 2010;24(12):1478-84
pubmed: 20858026
Crit Care Med. 2000 Jul;28(7):2293-9
pubmed: 10921555
JAMA. 1995 Nov 15;274(19):1511-7
pubmed: 7474219
Arch Gen Psychiatry. 2005 Jun;62(6):593-602
pubmed: 15939837
Intensive Care Med. 2013 Feb;39(2):165-228
pubmed: 23361625
Annu Rev Immunol. 2018 Apr 26;36:783-812
pubmed: 29677475
Front Immunol. 2017 Dec 15;8:1673
pubmed: 29326685
J Neurosci. 2012 Jul 18;32(29):9805-16
pubmed: 22815495
Gen Hosp Psychiatry. 2016 Nov - Dec;43:23-29
pubmed: 27796253
Front Neurosci. 2019 Apr 05;13:263
pubmed: 31024226
Surg Infect (Larchmt). 2016 Jun;17(3):286-93
pubmed: 27093228
Lancet. 2013 Feb 9;381(9865):496-505
pubmed: 23332146
BMJ Open. 2017 Feb 22;7(2):e014363
pubmed: 28232467
Anaesthesia. 2001 Jan;56(1):9-14
pubmed: 11167429
Am J Physiol Cell Physiol. 2006 Mar;290(3):C917-24
pubmed: 16267105
Science. 1986 Oct 24;234(4775):470-4
pubmed: 3764421
Annu Rev Pathol. 2006;1:297-329
pubmed: 18039117
N Engl J Med. 2014 Jan 30;370(5):444-54
pubmed: 24476433
Proc Natl Acad Sci U S A. 1986 May;83(10):3460-4
pubmed: 3486418
Front Microbiol. 2019 Aug 07;10:1676
pubmed: 31447793
J Intensive Care Med. 2014 Mar-Apr;29(2):87-95
pubmed: 23753224
Crit Care. 2014 Sep 03;18(5):469
pubmed: 25182529
J Gerontol A Biol Sci Med Sci. 2005 Sep;60(9):1180-3
pubmed: 16183960
Arch Intern Med. 2001 Nov 26;161(21):2602-7
pubmed: 11718592
Intensive Care Med. 2017 Mar;43(3):304-377
pubmed: 28101605
Am J Psychiatry. 2004 Jan;161(1):45-52
pubmed: 14702249
Crit Care Med. 2016 Oct;44(10):1833-41
pubmed: 27120256
Stroke. 2007 Mar;38(3):1044-9
pubmed: 17272778
Infect Immun. 2012 Jan;80(1):62-73
pubmed: 22006564
Crit Care Med. 2006 Jan;34(1):15-21
pubmed: 16374151
J Psychosom Res. 1997 Aug;43(2):121-3
pubmed: 9278902
J Immunol. 1971 Dec;107(6):1778-80
pubmed: 4941117
Am J Geriatr Psychiatry. 2006 May;14(5):401-9
pubmed: 16670244
Am J Respir Crit Care Med. 2016 Feb 1;193(3):259-72
pubmed: 26414292
J Adv Nurs. 2004 Jul;47(1):64-73
pubmed: 15186469
N Engl J Med. 2002 Apr 4;346(14):1061-6
pubmed: 11932474
Crit Care Med. 2018 Dec;46(12):1889-1897
pubmed: 30048332
JAMA. 2015 Mar 10;313(10):1055-7
pubmed: 25756444