Robust hepatitis E virus infection and transcriptional response in human hepatocytes.

Animals Antiviral Agents / pharmacology Carcinoma, Hepatocellular Cell Culture Techniques Cell Line, Tumor Genotype Hep G2 Cells Hepatitis E / metabolism Hepatitis E virus / drug effects Hepatocytes / virology Humans Liver Neoplasms / drug therapy Mice RNA-Dependent RNA Polymerase / genetics Replicon Ribavirin / metabolism Swine Viral Load Virus Replication

hepatitis E virus (HEV) humanized mice infection primary hepatocytes transcriptomics

Journal

Proceedings of the National Academy of Sciences of the United States of America

ISSN: 1091-6490

Titre abrégé: Proc Natl Acad Sci U S A

Pays: United States

ID NLM: 7505876

Informations de publication

Date de publication:
21 01 2020

Historique:

pubmed: 4 1 2020

medline: 28 4 2020

entrez: 4 1 2020

Statut: ppublish

Résumé

Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans and the leading cause for acute viral hepatitis worldwide. The virus is classified as a member of the genus

Identifiants

DOI: 10.1073/pnas.1912307117 PMID: 31896581 PMC: PMC6983376

pubmed: 31896581

pii: 1912307117

doi: 10.1073/pnas.1912307117

pmc: PMC6983376

doi:

Substances chimiques

Antiviral Agents 0

Ribavirin 49717AWG6K

RNA-Dependent RNA Polymerase EC 2.7.7.48

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

1731-1741

Informations de copyright

Déclaration de conflit d'intérêts

The authors declare no competing interest.

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