Neuroinflammation trajectories precede cognitive impairment after experimental meningitis-evidence from an in vivo PET study.
Cognition
Inflammation
Meningitis
Microglia
PET
Post-meningitis
TSPO
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
04 Jan 2020
04 Jan 2020
Historique:
received:
04
11
2019
accepted:
24
12
2019
entrez:
6
1
2020
pubmed:
7
1
2020
medline:
11
11
2020
Statut:
epublish
Résumé
Bacterial meningitis is a devastating central nervous system (CNS) infection with acute and long-term neurological consequences, including cognitive impairment. The aim of this study was to understand the association between activated microglia-induced neuroinflammation and post-meningitis cognitive impairment. Meningitis was induced in male Wistar rats by injecting Streptococcus pneumoniae into the brain through the cisterna magna, and rats were then treated with ceftriaxone. Twenty-four hours and 10 days after meningitis induction, rats were imaged with positron emission tomography (PET) using [ Both 24-h (acute) and 10-day (long-term) groups of rats demonstrated increased [ TSPO-PET could potentially be used as an imaging biomarker for microglial activation and long-term cognitive impairment post-meningitis. Additionally, this study opens a new avenue for the potential use of TSPO ligands after infection-induced neurological sequelae.
Sections du résumé
BACKGROUND
BACKGROUND
Bacterial meningitis is a devastating central nervous system (CNS) infection with acute and long-term neurological consequences, including cognitive impairment. The aim of this study was to understand the association between activated microglia-induced neuroinflammation and post-meningitis cognitive impairment.
METHOD
METHODS
Meningitis was induced in male Wistar rats by injecting Streptococcus pneumoniae into the brain through the cisterna magna, and rats were then treated with ceftriaxone. Twenty-four hours and 10 days after meningitis induction, rats were imaged with positron emission tomography (PET) using [
RESULTS
RESULTS
Both 24-h (acute) and 10-day (long-term) groups of rats demonstrated increased [
CONCLUSIONS
CONCLUSIONS
TSPO-PET could potentially be used as an imaging biomarker for microglial activation and long-term cognitive impairment post-meningitis. Additionally, this study opens a new avenue for the potential use of TSPO ligands after infection-induced neurological sequelae.
Identifiants
pubmed: 31901235
doi: 10.1186/s12974-019-1692-0
pii: 10.1186/s12974-019-1692-0
pmc: PMC6942362
doi:
Substances chimiques
Inflammation Mediators
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5Subventions
Organisme : Alzheimer's Association
ID : AARGDNTF-19-619645
Pays : United States
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