PET/MRI enables simultaneous


Journal

Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395

Informations de publication

Date de publication:
2020
Historique:
received: 22 01 2019
accepted: 02 10 2019
entrez: 7 1 2020
pubmed: 7 1 2020
medline: 7 4 2021
Statut: epublish

Résumé

Non-invasive imaging of β-cells represents a desirable preclinical and clinical tool to monitor the change of β-cell mass and the loss of function during pre-diabetic stages. Although it is widely accepted that manganese (Mn) ions are actively gated by voltage-dependent calcium channels (VDCC) in response to glucose metabolism, little is known on its specificity

Identifiants

pubmed: 31903128
doi: 10.7150/thno.33410
pii: thnov10p0398
pmc: PMC6929626
doi:

Substances chimiques

Calcium Channels 0
Glp1r protein, mouse 0
Glucagon-Like Peptide-1 Receptor 0
Radiopharmaceuticals 0
Manganese 42Z2K6ZL8P

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

398-410

Informations de copyright

© The author(s).

Déclaration de conflit d'intérêts

Competing Interests: B.J.P. has research collaborations with MEDISO, Hungary, on the development of small animal PET/MR and with Siemens on MR compatible PET electronics and breast PET/MR. M.G. is co-inventor of a patent on Exendin.

Références

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Auteurs

Filippo C Michelotti (FC)

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, Germany.

Gregory Bowden (G)

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, Germany.

Astrid Küppers (A)

Forschungszentrum Jülich GmbH, Central Institute of Engineering, Electronics and Analytics, Jülich, Germany.

Lieke Joosten (L)

Radboud University Medical Center, Department of Radiology and Nuclear Medicine, Nijmegen, The Netherlands.

Jonas Maczewsky (J)

Experimental Diabetology, Phamacology, Pharmaceutical Institute, Eberhard Karls University Tübingen, Tübingen, Germany.

Volker Nischwitz (V)

Forschungszentrum Jülich GmbH, Central Institute of Engineering, Electronics and Analytics, Jülich, Germany.

Gisela Drews (G)

Experimental Diabetology, Phamacology, Pharmaceutical Institute, Eberhard Karls University Tübingen, Tübingen, Germany.

Andreas Maurer (A)

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, Germany.
Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, Germany.

Martin Gotthardt (M)

Radboud University Medical Center, Department of Radiology and Nuclear Medicine, Nijmegen, The Netherlands.

Andreas M Schmid (AM)

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, Germany.

Bernd J Pichler (BJ)

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, Germany.
Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, Germany.

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Classifications MeSH