Liposomal delivery of hydrophobic RAMBAs provides good bioavailability and significant enhancement of retinoic acid signalling in neuroblastoma tumour cells.
Azoles
/ chemical synthesis
Cell Line, Tumor
Cell Survival
Gene Expression Regulation, Enzymologic
/ drug effects
Gene Expression Regulation, Neoplastic
/ drug effects
Humans
Liposomes
Neuroblastoma
Proto-Oncogene Proteins c-akt
/ genetics
Retinoic Acid 4-Hydroxylase
/ genetics
Signal Transduction
Tretinoin
/ agonists
CYP26
Neuroblastoma
RAMBA
liposome
neural differentiation
retinoic acid
Journal
Journal of drug targeting
ISSN: 1029-2330
Titre abrégé: J Drug Target
Pays: England
ID NLM: 9312476
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
pubmed:
7
1
2020
medline:
28
9
2021
entrez:
7
1
2020
Statut:
ppublish
Résumé
Retinoid treatment is employed during residual disease treatment in neuroblastoma, where the aim is to induce neural differentiation or death in tumour cells. However, although therapeutically effective, retinoids have only modest benefits and suffer from poor pharmacokinetic properties.
Identifiants
pubmed: 31903789
doi: 10.1080/1061186X.2019.1710157
pmc: PMC7609071
doi:
Substances chimiques
Azoles
0
Liposomes
0
Tretinoin
5688UTC01R
CYP26A1 protein, human
EC 1.14.14.1
CYP26B1 protein, human
EC 1.14.14.1
Retinoic Acid 4-Hydroxylase
EC 1.14.14.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
643-654Subventions
Organisme : Worldwide Cancer Research
ID : 12-1272
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
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