Fzd2 Contributes to Breast Cancer Cell Mesenchymal-Like Stemness and Drug Resistance.
Antineoplastic Agents
/ pharmacology
Breast Neoplasms
/ genetics
Cell Line, Tumor
Cell Movement
/ genetics
Cell Proliferation
/ genetics
Drug Resistance, Neoplasm
/ genetics
Epithelial-Mesenchymal Transition
/ genetics
Female
Frizzled Receptors
/ genetics
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Neoplastic Stem Cells
/ metabolism
Phenotype
Prognosis
Journal
Oncology research
ISSN: 1555-3906
Titre abrégé: Oncol Res
Pays: United States
ID NLM: 9208097
Informations de publication
Date de publication:
29 May 2020
29 May 2020
Historique:
pubmed:
8
1
2020
medline:
20
11
2020
entrez:
8
1
2020
Statut:
ppublish
Résumé
Cancer cell stemness is responsible for cancer relapse, distal metastasis, and drug resistance. Here we identified that Frizzled 2 (Fzd2), one member of Wnt receptor Frizzled family, induced human breast cancer (BC) cell stemness via noncanonical Wnt pathways. Fzd2 was overexpressed in human BC tissues, and Fzd2 overexpression was associated with an unfavorable outcome. Fzd2 knockdown (KD) disturbed the mesenchymal-like phenotype, migration, and invasion of BC cells. Moreover, Fzd2 KD impaired BC cell mammosphere formation, reduced Lgr5
Identifiants
pubmed: 31907106
doi: 10.3727/096504020X15783052025051
pmc: PMC7851528
doi:
Substances chimiques
Antineoplastic Agents
0
FZD2 protein, human
0
Frizzled Receptors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
273-284Références
Mol Cell. 2016 Jul 7;63(1):156-66
pubmed: 27292796
Diabetes. 2015 Apr;64(4):1235-48
pubmed: 25352637
Nat Cell Biol. 2015 Sep;17(9):1218-27
pubmed: 26258633
PLoS Genet. 2012;8(5):e1002723
pubmed: 22654675
Cancer Res. 2013 Sep 15;73(18):5821-33
pubmed: 23832666
Breast Cancer Res Treat. 2016 Dec;160(3):439-446
pubmed: 27744485
Oncogene. 2013 May 30;32(22):2767-81
pubmed: 22797058
Nature. 2015 Oct 1;526(7571):131-5
pubmed: 26416748
Cancer Sci. 2018 Nov;109(11):3368-3375
pubmed: 30137666
Cancer Res. 2014 Mar 1;74(5):1566-75
pubmed: 24413534
Oncogene. 2019 May;38(20):3794-3811
pubmed: 30692635
Mol Cancer Res. 2012 Oct;10(10):1369-79
pubmed: 22912337
Nat Cell Biol. 2014 Oct;16(10):1004-15, 1-13
pubmed: 25241036
DNA Cell Biol. 2017 Jan;36(1):58-66
pubmed: 27828711
Nature. 2015 Dec 24;528(7583):560-564
pubmed: 26649819
Stem Cells. 2014 Oct;32(10):2571-82
pubmed: 24891218
Nat Commun. 2016 Feb 15;7:10498
pubmed: 26876920
Cancer Res. 2018 Aug 15;78(16):4497-4511
pubmed: 29748375
Trends Cell Biol. 2018 May;28(5):380-391
pubmed: 29477614
Nat Cell Biol. 2016 Sep 19;18(10):1078-1089
pubmed: 27642788
J Natl Cancer Inst. 2010 Nov 3;102(21):1637-52
pubmed: 20935265
EMBO J. 2010 Jan 6;29(1):41-54
pubmed: 19910923
Mol Cancer Res. 2016 Jan;14(1):103-13
pubmed: 26507575
Stem Cell Reports. 2013 Dec 27;2(1):78-91
pubmed: 24511467
Nat Commun. 2016 Mar 31;7:11123
pubmed: 27030211
Nat Med. 2012 Oct;18(10):1511-7
pubmed: 23001183
Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9640-E9648
pubmed: 30242135
Cancer Lett. 2018 Oct 1;433:259-272
pubmed: 30026175
Cancer Res. 2017 Sep 15;77(18):4894-4904
pubmed: 28887324
Nature. 2015 Sep 3;525(7567):114-8
pubmed: 26266975
EMBO Mol Med. 2013 Feb;5(2):264-79
pubmed: 23307470
Cancer Res. 2017 Sep 15;77(18):4868-4880
pubmed: 28754671
Science. 2012 Aug 10;337(6095):730-5
pubmed: 22855427
Oncotarget. 2016 Jun 21;7(25):37790-37802
pubmed: 27191257
PLoS Biol. 2006 Apr;4(4):e115
pubmed: 16602827
Cancer Res. 2009 Jul 1;69(13):5364-73
pubmed: 19549913
Oncogene. 2011 Oct 27;30(43):4437-46
pubmed: 21532620
Nat Commun. 2015 Dec 16;6:10186
pubmed: 26671411
J Biol Chem. 2015 Mar 13;290(11):6789-98
pubmed: 25605717
Oncogene. 2018 Mar;37(10):1399-1408
pubmed: 29249801
Clin Cancer Res. 2008 Oct 15;14(20):6556-63
pubmed: 18927296
Nature. 2017 May 11;545(7653):187-192
pubmed: 28355176
J Exp Clin Cancer Res. 2015 Dec 30;34:159
pubmed: 26714461
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2778-83
pubmed: 21633010
Cell. 2015 Aug 13;162(4):780-94
pubmed: 26276632
Cell. 2016 Jun 30;166(1):47-62
pubmed: 27368100
Cell Metab. 2018 Jan 9;27(1):136-150.e5
pubmed: 29249690
Cancer Res. 2016 Jun 1;76(11):3397-410
pubmed: 27197172
Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10532-E10539
pubmed: 29158396
Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2441-50
pubmed: 22891335
J Clin Invest. 2011 Jul;121(7):2723-35
pubmed: 21633165
Nat Med. 2011 Jun 26;17(7):867-74
pubmed: 21706029
J Pathol. 2017 Feb;241(3):350-361
pubmed: 27859262