Recurrent chromosomal rearrangements of
Adenoma, Liver Cell
/ genetics
Adult
Cytokine Receptor gp130
/ genetics
Female
Gene Expression Profiling
/ statistics & numerical data
Gene Rearrangement
/ immunology
Humans
Inflammation
/ genetics
Janus Kinases
/ metabolism
Liver Neoplasms
/ genetics
Male
Mutation
Neoplasm Proteins
/ genetics
Protein-Tyrosine Kinases
/ genetics
Proto-Oncogene Proteins
/ genetics
STAT Transcription Factors
/ metabolism
Signal Transduction
/ genetics
hepatocellular carcinoma
inflammation
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
04
09
2019
revised:
27
11
2019
accepted:
14
12
2019
pubmed:
8
1
2020
medline:
7
4
2021
entrez:
8
1
2020
Statut:
ppublish
Résumé
Inflammatory hepatocellular adenomas (IHCAs) are benign liver tumours characterised by an activation of the janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway caused by oncogenic activating mutations. However, a subset of IHCA lacks of identified mutation explaining the inflammatory phenotype. 657 hepatocellular adenomas developed in 504 patients were analysed for gene expression of 17 genes and for mutations in seven genes by sequencing. 22 non-mutated IHCAs were analysed by whole-exome and/or RNA sequencing. We identified 296 IHCA (45%), 81% of them were mutated in either Recurrent chromosomal alterations involving
Sections du résumé
BACKGROUND
Inflammatory hepatocellular adenomas (IHCAs) are benign liver tumours characterised by an activation of the janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway caused by oncogenic activating mutations. However, a subset of IHCA lacks of identified mutation explaining the inflammatory phenotype.
METHODS
657 hepatocellular adenomas developed in 504 patients were analysed for gene expression of 17 genes and for mutations in seven genes by sequencing. 22 non-mutated IHCAs were analysed by whole-exome and/or RNA sequencing.
RESULTS
We identified 296 IHCA (45%), 81% of them were mutated in either
CONCLUSION
Recurrent chromosomal alterations involving
Identifiants
pubmed: 31907296
pii: gutjnl-2019-319790
doi: 10.1136/gutjnl-2019-319790
doi:
Substances chimiques
IL6ST protein, human
0
Neoplasm Proteins
0
Proto-Oncogene Proteins
0
STAT Transcription Factors
0
Cytokine Receptor gp130
133483-10-0
Protein-Tyrosine Kinases
EC 2.7.10.1
ROS1 protein, human
EC 2.7.10.1
FRK protein, human
EC 2.7.10.2
Janus Kinases
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1667-1676Informations de copyright
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.