Hyaluronan deposition in islets may precede and direct the location of islet immune-cell infiltrates.
Adult
Aged
Aged, 80 and over
Animals
Autoantibodies
/ metabolism
Case-Control Studies
Chemotaxis, Leukocyte
/ immunology
Diabetes Mellitus, Type 1
/ immunology
Disease Models, Animal
Extracellular Matrix
/ metabolism
Female
Humans
Hyaluronic Acid
/ metabolism
Insulin
/ metabolism
Insulin-Secreting Cells
/ immunology
Islets of Langerhans
/ metabolism
Male
Middle Aged
Pancreas
/ immunology
Pancreatic Diseases
/ immunology
Rats
Autoantibodies
Extracellular matrix
Hyaluronan
Insulitis
Islet
Type 1 diabetes
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
18
04
2019
accepted:
10
10
2019
pubmed:
8
1
2020
medline:
2
4
2021
entrez:
8
1
2020
Statut:
ppublish
Résumé
Substantial deposition of the extracellular matrix component hyaluronan (HA) is characteristic of insulitis in overt type 1 diabetes. We investigated whether HA accumulation is detectable in islets early in disease pathogenesis and how this affects the development of insulitis and beta cell mass. Pancreas tissue from 15 non-diabetic organ donors who were positive for islet autoantibodies (aAbs) and from 14 similarly aged aAb Abundant islet HA deposits were observed in pancreas tissues from n = 3 single- and n = 4 double-aAb This study indicates that HA deposition in islets occurs early in type 1 diabetes and prior to insulitis, and points to a potential role of HA in triggering islet immune-cell infiltration and the promotion of insulitis.
Identifiants
pubmed: 31907557
doi: 10.1007/s00125-019-05066-7
pii: 10.1007/s00125-019-05066-7
pmc: PMC7002022
mid: NIHMS1548329
doi:
Substances chimiques
Autoantibodies
0
Insulin
0
Hyaluronic Acid
9004-61-9
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
549-560Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI101990
Pays : United States
Organisme : Helmsley Charitable Trust George S. Eisenbarth nPOD Award for Team Science
ID : 2015PG T1D052
Pays : International
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