Early and very early-onset schizophrenia compared with adult-onset schizophrenia: French FACE-SZ database.
adult-onset schizophrenia
duration of untreated psychosis
early-onset schizophrenia
symptomatology
very early-onset schizophrenia
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
12
06
2019
revised:
06
11
2019
accepted:
11
11
2019
pubmed:
8
1
2020
medline:
29
12
2020
entrez:
8
1
2020
Statut:
ppublish
Résumé
To compare the clinical symptomatology in patients with Early-Onset Schizophrenia (EOS, N = 176), especially the subgroup Very Early Onset Schizophrenia (VEOS) and Adult Onset Schizophrenia (AOS, N = 551). In a large French multicentric sample, 727 stable schizophrenia patients, classified by age at onset of the disorder, were assessed using standardized and extensive clinical and neuropsychological batteries: AOS with onset ≥ 18 years and EOS with onset < 18 years (including 22 VEOS < 13 years). The importance of better diagnosing EOS group, and in particularly VEOS, appeared in a longer DUP Duration of Untreated Psychosis (respectively, 2.6 years ± 4.1 and 8.1 years ± 5.7 vs. 1.0 years ± 2.5), more severe symptomatology (PANSS Positive And Negative Syndrome Scale scores), and lower educational level than the AOS group. In addition, the VEOS subgroup had a more frequent childhood history of learning disabilities and lower prevalence of right-handedness quotient than the AOS. The study demonstrates the existence of an increased gradient of clinical severity from AOS to VEOS. In order to improve the prognosis of the early forms of schizophrenia and to reduce the DUP, clinicians need to pay attention to the prodromal manifestations of the disease.
Identifiants
pubmed: 31908151
doi: 10.1002/brb3.1495
pmc: PMC7010576
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e01495Subventions
Organisme : Assistance Publique des Hôpitaux de Paris (APHP)
Pays : International
Organisme : Foundation FondaMental
Pays : International
Informations de copyright
© 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
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