Phase-dependent modulation of cortical and thalamic sensory responses during spike-and-wave discharges.
absence epilepsy
cortex
electrocorticogram
intracellular
sensory-evoked potentials
thalamus
Journal
Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
17
07
2019
revised:
14
12
2019
accepted:
16
12
2019
pubmed:
9
1
2020
medline:
11
7
2020
entrez:
9
1
2020
Statut:
ppublish
Résumé
The neuronal underpinnings of impaired consciousness during absence seizures remain largely unknown. Spike-and-wave (SW) activity associated with absences imposes two extremely different states in cortical neurons, which transition from suprathreshold synaptic depolarizations during spike phases to membrane hyperpolarization and electrical silence during wave phases. To investigate whether this rhythmic alternation of neuronal states affects the processing of sensory information during seizures, we examined cortical and thalamic responsiveness to brief sensory stimuli in the different phases of the epileptic cycle. Electrocorticographic (ECoG) monitoring from the primary somatosensory cortex combined with intracellular recordings of subjacent pyramidal neurons, or extracellular recordings of somatosensory thalamic neurons, were performed in the Genetic Absence Epilepsy Rat From Strasbourg. Sensory stimuli consisted of pulses of compressed air applied to the contralateral whiskers. Whisker stimuli delivered during spike phases evoked smaller depolarizing synaptic potentials and fewer action potentials in cortical neurons compared to stimuli occurring during wave phases. This spike-related attenuation of cortical responsiveness was accompanied by a reduced neuronal membrane resistance, likely due to the large increase in synaptic conductance. Sensory-evoked firing in thalamocortical neurons was also decreased during ECoG spikes as compared to wave phases, indicating that time-to-time changes in the thalamocortical volley may also contribute to the variability of cortical responses during seizures. These findings demonstrate that thalamocortical sensory processing during absence seizures is nonstationary and strongly suggest that the cortical impact of a given environmental stimulus is conditioned by its exact timing relative to the SW cycle. The lack of stability of thalamic and cortical responses along seizures may contribute to impaired conscious sensory perception during absences.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
330-341Subventions
Organisme : program 'Investissements d'avenir'
ID : ANR-10-IAIHU-06
Pays : International
Organisme : Institut National de la Santé et de la Recherche Médicale
Pays : International
Organisme : Fondation pour la Recherche sur le Cerveau
ID : FRC-2016
Pays : International
Organisme : Agence Nationale de la Recherche
ID : ANR-16-CE37-0021 2016
Pays : International
Informations de copyright
Wiley Periodicals, Inc. © 2020 International League Against Epilepsy.
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