CREB Family Transcription Factors Are Major Mediators of BDNF Transcriptional Autoregulation in Cortical Neurons.
Animals
Basic-Leucine Zipper Transcription Factors
/ physiology
Brain-Derived Neurotrophic Factor
/ biosynthesis
Cells, Cultured
Cerebral Cortex
/ cytology
Cyclic AMP Response Element-Binding Protein
/ physiology
Cytoskeletal Proteins
/ biosynthesis
Feedback, Physiological
Female
Gene Expression Regulation
/ genetics
Genes, Dominant
Genes, Reporter
Genes, Synthetic
Hippocampus
/ cytology
MAP Kinase Signaling System
/ physiology
Male
Nerve Tissue Proteins
/ biosynthesis
Neurons
/ metabolism
Promoter Regions, Genetic
Protein Kinase Inhibitors
/ pharmacology
Rats
Rats, Sprague-Dawley
Receptor, trkB
/ physiology
Recombinant Proteins
/ pharmacology
Response Elements
Signal Transduction
/ physiology
Species Specificity
Transcription, Genetic
/ genetics
Transduction, Genetic
BDNF
CBP
CREB
TrkB
positive feedback loop
transcription
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
12 02 2020
12 02 2020
Historique:
received:
14
02
2019
revised:
10
12
2019
accepted:
28
12
2019
pubmed:
10
1
2020
medline:
20
8
2020
entrez:
10
1
2020
Statut:
ppublish
Résumé
BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating its own expression levels in neurons, forming a transcriptional positive feedback loop. In the current study, we have investigated this phenomenon in primary cultures of rat cortical neurons using overexpression of dominant-negative forms of several transcription factors, including CREB, ATF2, C/EBP, USF, and NFAT. We show that CREB family transcription factors, together with the coactivator CBP/p300, but not the CRTC family, are the main regulators of rat
Identifiants
pubmed: 31915257
pii: JNEUROSCI.0367-19.2019
doi: 10.1523/JNEUROSCI.0367-19.2019
pmc: PMC7044735
doi:
Substances chimiques
Basic-Leucine Zipper Transcription Factors
0
Bdnf protein, rat
0
Brain-Derived Neurotrophic Factor
0
Creb1 protein, rat
0
Cyclic AMP Response Element-Binding Protein
0
Cytoskeletal Proteins
0
Nerve Tissue Proteins
0
Protein Kinase Inhibitors
0
Recombinant Proteins
0
activity regulated cytoskeletal-associated protein
0
BDNF protein, human
7171WSG8A2
Ntrk2 protein, rat
EC 2.7.10.1
Receptor, trkB
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1405-1426Informations de copyright
Copyright © 2020 the authors.
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