Microbiota-targeted maternal antibodies protect neonates from enteric infection.
Animals
Antibodies
/ blood
Breast Feeding
Cross Reactions
/ immunology
Enterotoxigenic Escherichia coli
/ immunology
Escherichia coli Infections
/ immunology
Female
Humans
Immunity, Maternally-Acquired
/ immunology
Immunoglobulin G
/ blood
Infant, Newborn
/ immunology
Male
Mice
Microbiota
/ immunology
Milk, Human
/ immunology
Mothers
Pantoea
/ immunology
Receptors, Fc
/ immunology
Symbiosis
/ immunology
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
09
11
2018
accepted:
01
11
2019
pubmed:
10
1
2020
medline:
8
5
2020
entrez:
10
1
2020
Statut:
ppublish
Résumé
Although maternal antibodies protect newborn babies from infection
Identifiants
pubmed: 31915378
doi: 10.1038/s41586-019-1898-4
pii: 10.1038/s41586-019-1898-4
pmc: PMC7362890
mid: NIHMS1582436
doi:
Substances chimiques
Antibodies
0
Immunoglobulin G
0
Receptors, Fc
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
543-548Subventions
Organisme : NIAID NIH HHS
ID : 1U19 AI109764
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI018045
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109764
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI018045
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK102771
Pays : United States
Références
Basha, S., Surendran, N. & Pichichero, M. Immune responses in neonates. Expert Rev. Clin. Immunol. 10, 1171–1184 (2014).
pubmed: 25088080
pmcid: 4407563
doi: 10.1586/1744666X.2014.942288
Simon, A. K., Hollander, G. A. & McMichael, A. Evolution of the immune system in humans from infancy to old age. Proc. R. Soc. B 282, 20143085 (2015).
pubmed: 26702035
doi: 10.1098/rspb.2014.3085
pmcid: 4707740
Kamada, N., Chen, G. Y., Inohara, N. & Núñez, G. Control of pathogens and pathobionts by the gut microbiota. Nat. Immunol. 14, 685–690 (2013).
pubmed: 23778796
pmcid: 4083503
doi: 10.1038/ni.2608
Carbonare, C. B., Carbonare, S. B. & Carneiro-Sampaio, M. M. S. Secretory immunoglobulin A obtained from pooled human colostrum and milk for oral passive immunization. Pediatr. Allergy Immunol. 16, 574–581 (2005).
pubmed: 16238582
doi: 10.1111/j.1399-3038.2005.00332.x
Hanson, L. A. R. & Korotkova, M. The role of breastfeeding in prevention of neonatal infection. Semin. Neonatol. 7, 275–281 (2002).
pubmed: 12401297
doi: 10.1053/siny.2002.0124
Madoff, L. C., Michel, J. L., Gong, E. W., Rodewald, A. K. & Kasper, D. L. Protection of neonatal mice from group B streptococcal infection by maternal immunization with beta C protein. Infect. Immun. 60, 4989–4994 (1992).
pubmed: 1452329
pmcid: 258267
doi: 10.1128/IAI.60.12.4989-4994.1992
Zaman, K. et al. Effectiveness of maternal influenza immunization in mothers and infants. N. Engl. J. Med. 359, 1555–1564 (2008).
pubmed: 18799552
doi: 10.1056/NEJMoa0708630
Englund, J. A. et al. Transplacental antibody transfer following maternal immunization with polysaccharide and conjugate Haemophilus influenzae type b vaccines. J. Infect. Dis. 171, 99–105 (1995).
pubmed: 7798688
doi: 10.1093/infdis/171.1.99
Kearney, J. F., Patel, P., Stefanov, E. K. & King, R. G. Natural antibody repertoires: development and functional role in inhibiting allergic airway disease. Annu. Rev. Immunol. 33, 475–504 (2015).
pubmed: 25622195
doi: 10.1146/annurev-immunol-032713-120140
Macpherson, A. J., de Agüero, M. G. & Ganal-Vonarburg, S. C. How nutrition and the maternal microbiota shape the neonatal immune system. Nat. Rev. Immunol. 17, 508–517 (2017).
pubmed: 28604736
doi: 10.1038/nri.2017.58
Chen, Y. et al. Microbial symbionts regulate the primary Ig repertoire. J. Exp. Med. 215, 1397–1415 (2018).
pubmed: 29588346
pmcid: 5940265
doi: 10.1084/jem.20171761
Englund, J. A. et al. Maternal immunization with influenza or tetanus toxoid vaccine for passive antibody protection in young infants. J. Infect. Dis. 168, 647–656 (1993).
pubmed: 8354906
doi: 10.1093/infdis/168.3.647
Boes, M., Prodeus, A. P., Schmidt, T., Carroll, M. C. & Chen, J. A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection. J. Exp. Med. 188, 2381–2386 (1998).
pubmed: 9858525
pmcid: 2212438
doi: 10.1084/jem.188.12.2381
Ochsenbein, A. F. et al. Control of early viral and bacterial distribution and disease by natural antibodies. Science 286, 2156–2159 (1999).
pubmed: 10591647
doi: 10.1126/science.286.5447.2156
Baumgarth, N. et al. B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection. J. Exp. Med. 192, 271–280 (2000).
pubmed: 10899913
pmcid: 2193249
doi: 10.1084/jem.192.2.271
Jayasekera, J. P., Moseman, E. A. & Carroll, M. C. Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity. J. Virol. 81, 3487–3494 (2007).
pubmed: 17202212
pmcid: 1866020
doi: 10.1128/JVI.02128-06
Zhou, Z. H. et al. The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies. Cell Host Microbe 1, 51–61 (2007).
pubmed: 18005681
pmcid: 2212603
doi: 10.1016/j.chom.2007.01.002
Caballero-Flores, G. et al. Maternal immunization confers protection to the offspring against an attaching and effacing pathogen through delivery of IgG in breast milk. Cell Host Microbe 25, 313–323 (2019).
pubmed: 30686564
doi: 10.1016/j.chom.2018.12.015
pmcid: 6375740
Palmeira, P., Quinello, C., Silveira-Lessa, A. L., Zago, C. A. & Carneiro-Sampaio, M. IgG placental transfer in healthy and pathological pregnancies. Clin. Dev. Immunol. 2012, 985646 (2012).
pubmed: 22235228
doi: 10.1155/2012/985646
Masuda, A. et al. Fcγ receptor regulation of Citrobacter rodentium infection. Infect. Immun. 76, 1728–1737 (2008).
pubmed: 18227164
pmcid: 2292883
doi: 10.1128/IAI.01493-07
Pyzik, M., Rath, T., Lencer, W. I., Baker, K. & Blumberg, R. S. FcRn: the architect behind the immune and nonimmune functions of IgG and albumin. J. Immunol. 194, 4595–4603 (2015).
pubmed: 25934922
doi: 10.4049/jimmunol.1403014
Israel, E. J. et al. Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells. Immunology 92, 69–74 (1997).
pubmed: 9370926
pmcid: 1363983
doi: 10.1046/j.1365-2567.1997.00326.x
Kotloff, K. L. et al. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case–control study. Lancet 382, 209–222 (2013).
pubmed: 23680352
doi: 10.1016/S0140-6736(13)60844-2
Kotloff, K. L. et al. Global burden of diarrheal diseases among children in developing countries: incidence, etiology, and insights from new molecular diagnostic techniques. Vaccine 35, 6783–6789 (2017).
pubmed: 28765005
doi: 10.1016/j.vaccine.2017.07.036
Kotloff, K. L. et al. The incidence, aetiology, and adverse clinical consequences of less severe diarrhoeal episodes among infants and children residing in low-income and middle-income countries: a 12-month case–control study as a follow-on to the Global Enteric Multicenter Study (GEMS). Lancet Glob. Health 7, e568–e584 (2019).
pubmed: 31000128
pmcid: 6484777
doi: 10.1016/S2214-109X(19)30076-2
Qadri, F., Svennerholm, A.-M., Faruque, A. S. G. & Sack, R. B. Enterotoxigenic Escherichia coli in developing countries: epidemiology, microbiology, clinical features, treatment, and prevention. Clin. Microbiol. Rev. 18, 465–483 (2005).
pubmed: 16020685
pmcid: 1195967
doi: 10.1128/CMR.18.3.465-483.2005
Thapar, N. & Sanderson, I. R. Diarrhoea in children: an interface between developing and developed countries. Lancet 363, 641–653 (2004).
pubmed: 14987892
doi: 10.1016/S0140-6736(04)15599-2
Skurnik, D., Cywes-Bentley, C. & Pier, G. B. The exceptionally broad-based potential of active and passive vaccination targeting the conserved microbial surface polysaccharide PNAG. Expert Rev. Vaccines 15, 1041–1053 (2016).
pubmed: 26918288
pmcid: 4985264
doi: 10.1586/14760584.2016.1159135
Le Gallou, S. et al. A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses. J. Exp. Med. 215, 2035–2053 (2018).
pubmed: 29959173
pmcid: 6080908
doi: 10.1084/jem.20180977
Wilmore, J. R. et al. Commensal microbes induce serum IgA responses that protect against polymicrobial sepsis. Cell Host Microbe 23, 302–311 (2018).
pubmed: 29478774
pmcid: 6350773
doi: 10.1016/j.chom.2018.01.005
Apter, F. M. et al. Analysis of the roles of antilipopolysaccharide and anti-cholera toxin immunoglobulin A (IgA) antibodies in protection against Vibrio cholerae and cholera toxin by use of monoclonal IgA antibodies in vivo. Infect. Immun. 61, 5279–5285 (1993).
pubmed: 8225601
pmcid: 281312
doi: 10.1128/IAI.61.12.5279-5285.1993
Michetrti, P., Mahan, M. J., Slauch, J. M., Mekalanos, J. J. & Neutra, M. R. Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium. Infect. Immun. 60, 1786–1792 (1992).
doi: 10.1128/IAI.60.5.1786-1792.1992
Moor, K. et al. High-avidity IgA protects the intestine by enchaining growing bacteria. Nature 544, 498–502 (2017).
pubmed: 28405025
doi: 10.1038/nature22058
Stuebe, A. The risks of not breastfeeding for mothers and infants. Rev. Obstet. Gynecol. 2, 222–231 (2009).
pubmed: 20111658
pmcid: 2812877
Goldsmith, S. J., Dickson, J. S., Barnhart, H. M., Toledo, R. T. & Eiten-Miller, R. R. IgA, IgG, IgM and lactoferrin contents of human milk during early lactation and the effect of processing and storage. J. Food Prot. 46, 4–7 (1983).
pubmed: 30913698
doi: 10.4315/0362-028X-46.1.4
Fouda, G. G. et al. HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies. J. Virol. 85, 9555–9567 (2011).
pubmed: 21734046
pmcid: 3165739
doi: 10.1128/JVI.05174-11
Dickinson, B. L. et al. Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line. J. Clin. Invest. 104, 903–911 (1999).
pubmed: 10510331
pmcid: 408555
doi: 10.1172/JCI6968
Bournazos, S. & Ravetch, J. V. Diversification of IgG effector functions. Int. Immunol. 29, 303–310 (2017).
pubmed: 28472280
pmcid: 5890892
doi: 10.1093/intimm/dxx025
Mostov, K. E. Transepithelial transport of immunoglobulins. Annu. Rev. Immunol. 12, 63–84 (1994).
pubmed: 8011293
doi: 10.1146/annurev.iy.12.040194.000431
Yoshida, M. et al. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity 20, 769–783 (2004).
pubmed: 15189741
doi: 10.1016/j.immuni.2004.05.007
Caporaso, J. G. et al. Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample. Proc. Natl Acad. Sci. USA 108, 4516–4522 (2011).
pubmed: 20534432
doi: 10.1073/pnas.1000080107
Bolyen, E. et al. Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat. Biotechnol. 37, 852–857 (2019).
pubmed: 31341288
doi: 10.1038/s41587-019-0209-9
pmcid: 7015180
Suzuki, M. T. & Giovannoni, S. J. Bias caused by template annealing in the amplification of mixtures of 16S rRNA genes by PCR. Appl. Environ. Microbiol. 62, 625–630 (1996).
pubmed: 8593063
pmcid: 167828
doi: 10.1128/AEM.62.2.625-630.1996
Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).
pubmed: 25516281
pmcid: 4302049
doi: 10.1186/s13059-014-0550-8