Rosuvastatin protects isolated hearts against ischemia-reperfusion injury: role of Akt-GSK-3β, metabolic environment, and mitochondrial permeability transition pore.
Animals
Cardiotonic Agents
/ therapeutic use
Female
Glycogen Synthase Kinase 3 beta
/ metabolism
Heart
/ drug effects
In Vitro Techniques
Mitochondria, Heart
/ drug effects
Mitochondrial Membrane Transport Proteins
/ metabolism
Mitochondrial Permeability Transition Pore
Myocardial Infarction
/ pathology
Myocardial Reperfusion Injury
/ drug therapy
Proto-Oncogene Proteins c-akt
/ metabolism
Rats
Rats, Wistar
Rosuvastatin Calcium
/ therapeutic use
Akt
Cardioprotection
GSK-3β
Ischemia-reperfusion
MPTP
Rosuvastatin
Journal
Journal of physiology and biochemistry
ISSN: 1877-8755
Titre abrégé: J Physiol Biochem
Pays: Spain
ID NLM: 9812509
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
10
05
2019
accepted:
28
11
2019
pubmed:
10
1
2020
medline:
9
10
2020
entrez:
10
1
2020
Statut:
ppublish
Résumé
The cardioprotective activity of rosuvastatin (R) is yet to be known. The objective of this study was to research whether R perfusion before global ischemia can mitigate myocardial ischemia-reperfusion damage, considering the metabolic condition in which these effects occur, and to contemplate potential mitochondrial benefits. Protein kinase B (Akt)/glycogen synthase kinase-3β (GSK-3β) and mitochondrial permeability transition pore (MPTP) are key elements in myocardial injury produced by ischemia-reperfusion. Isolated rat hearts were subjected to 25-min ischemia and 1-h reperfusion in the presence or absence of R, with or without Wortmannin (W), a phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor. Akt and GSK-3β were measured by Western blot analysis; lactate, glycogen, and G6PDH were determined; and Ca
Identifiants
pubmed: 31916218
doi: 10.1007/s13105-019-00718-z
pii: 10.1007/s13105-019-00718-z
doi:
Substances chimiques
Cardiotonic Agents
0
Mitochondrial Membrane Transport Proteins
0
Mitochondrial Permeability Transition Pore
0
Rosuvastatin Calcium
83MVU38M7Q
Glycogen Synthase Kinase 3 beta
EC 2.7.11.1
Gsk3b protein, rat
EC 2.7.11.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
85-98Références
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