Organ blood flow in response to infusion of arginine vasopressin in premature fetal sheep.
Adrenal Glands
/ blood supply
Animals
Arginine Vasopressin
/ pharmacology
Coronary Vessels
/ drug effects
Female
Fetal Blood
/ drug effects
Fetus
/ drug effects
Hemostatics
/ pharmacology
Medulla Oblongata
/ blood supply
Pregnancy
Regional Blood Flow
/ drug effects
Sheep
Vascular Resistance
/ drug effects
arginine vasopressin
microspheres
premature infant
sheep
vascular resistance
Journal
Pediatrics international : official journal of the Japan Pediatric Society
ISSN: 1442-200X
Titre abrégé: Pediatr Int
Pays: Australia
ID NLM: 100886002
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
01
11
2018
revised:
26
12
2019
accepted:
07
01
2020
pubmed:
10
1
2020
medline:
20
1
2021
entrez:
10
1
2020
Statut:
ppublish
Résumé
Arginine vasopressin (AVP) infusion has been shown to be a useful strategy for the management of systemic perfusion failure in premature infants. Our objective was to determine the characteristics of the blood flow redistribution induced by AVP infusion in premature fetal sheep. Nine sheep fetuses at 99 to 113 days of gestation were continuously infused with AVP. Measurement of blood flow to individual fetal organs was performed using a colored microsphere technique, with measurements performed at 30 min before and 90 min after the initiation of AVP infusions. The AVP infusion significantly increased blood flow to the medulla oblongata (P < 0.05), and significantly decreased flow to the adrenal glands (from 492.0 ± 239.6 to 364.9 ± 143.3 mL/min/100 g, P < 0.05) and heart (from 592.6 ± 184.5 to 435.6 ± 137.4 mL/min/100 g, P < 0.05). The infusion significantly increased the vascular resistance in adrenal glands, kidneys, ileum, colon, heart, and cerebellum. In the brain, except for the cerebellum, no significant increase in resistance was identified. There was no significant response to AVP infusion in cerebral blood flow in mid-gestation fetal sheep. Our observations suggest that, under AVP stimulation, the blood flow to the adrenal glands and myocardium might be decreased due to an increase in vascular resistance.
Sections du résumé
BACKGROUND
BACKGROUND
Arginine vasopressin (AVP) infusion has been shown to be a useful strategy for the management of systemic perfusion failure in premature infants. Our objective was to determine the characteristics of the blood flow redistribution induced by AVP infusion in premature fetal sheep.
METHODS
METHODS
Nine sheep fetuses at 99 to 113 days of gestation were continuously infused with AVP. Measurement of blood flow to individual fetal organs was performed using a colored microsphere technique, with measurements performed at 30 min before and 90 min after the initiation of AVP infusions.
RESULTS
RESULTS
The AVP infusion significantly increased blood flow to the medulla oblongata (P < 0.05), and significantly decreased flow to the adrenal glands (from 492.0 ± 239.6 to 364.9 ± 143.3 mL/min/100 g, P < 0.05) and heart (from 592.6 ± 184.5 to 435.6 ± 137.4 mL/min/100 g, P < 0.05). The infusion significantly increased the vascular resistance in adrenal glands, kidneys, ileum, colon, heart, and cerebellum. In the brain, except for the cerebellum, no significant increase in resistance was identified.
CONCLUSIONS
CONCLUSIONS
There was no significant response to AVP infusion in cerebral blood flow in mid-gestation fetal sheep. Our observations suggest that, under AVP stimulation, the blood flow to the adrenal glands and myocardium might be decreased due to an increase in vascular resistance.
Substances chimiques
Hemostatics
0
Arginine Vasopressin
113-79-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
688-693Subventions
Organisme : Japan Society for the Promotion of Science
ID : JP21791030
Organisme : Japan Society for the Promotion of Science
ID : JP26893013
Informations de copyright
© 2020 Japan Pediatric Society.
Références
Richardson B, Korkola S, Asano H, Challis J, Polk D, Fraser M. Regional blood flow and the endocrine response to sustained hypoxemia in the preterm ovine fetus. Pediatr. Res. 1996; 40: 337-43.
Rurak DW, Richardson BS, Patrick JE, Carmichael L, Homan J. Blood flow and oxygen delivery to fetal organs and tissues during sustained hypoxemia. Am. J. Physiol. 1990; 258: R1116-22.
Rurak DW. Plasma vasopressin levels during hypoxaemia and the cardiovascular effects of exogenous vasopressin in foetal and adult sheep. J. Physiol. 1978; 277: 341-57.
Faucher DJ, Laptook AR, Porter JC, Rosenfeld CR. Effects of acute hypercapnia on maternal and fetal vasopressin and catecholamine release. Pediatr. Res. 1991; 30: 368-74.
Alexander DP, Britton HG, Forsling ML, Nixon DA, Ratcliffe JG. Pituitary and plasma concentrations of adrenocorticotrophin, growth hormone, vasopressin and oxytocin in fetal and maternal sheep during the latter half of gestation and the response to haemorrhage. Biol. Neonate. 1974; 24: 206-19.
Iwamoto HS, Rudolph AM, Keil LC, Heymann MA. Hemodynamic responses of the sheep fetus to vasopressin infusion. Circ. Res. 1979; 44: 430-6.
Perez R, Espinoza M, Riquelme R, Parer JT, Llanos AJ. Arginine vasopressin mediates cardiovascular responses to hypoxemia in fetal sheep. Am. J. Physiol. 1989; 256: R1011-8.
Fletcher AJ, Gardner DS, Edwards CM, Fowden AL, Giussani DA. Development of the ovine fetal cardiovascular defense to hypoxemia towards full term. Am. J. Physiol. Heart Circ. Physiol. 2006; 291: H3023-34.
Raff H, Kane CW, Wood CE. Arginine vasopressin responses to hypoxia and hypercapnia in late-gestation fetal sheep. Am. J. Physiol. 1991; 260: R1077-81.
Mason JI, Hemsell PG, Korte K. Steroidogenesis in dispersed cells of human fetal adrenal. J. Clin. Endocrinol. Metab. 1983; 56: 1057-62.
Mesiano S, Jaffe RB. Developmental and functional biology of the primate fetal adrenal cortex. Endocr. Rev. 1997; 18: 378-403.
Kristi LW. Fetal and Neonatal Adrenocortical Physiology. In: Richard AP, William WF, Steven HA (eds). Fetal and Neonatal Physiology, 4th edn. Saunders, Philadelphia, PA, 2014; 1995-2004.
Masumoto K, Kusuda S, Aoyagi H et al. Comparison of serum cortisol concentrations in preterm infants with or without late-onset circulatory collapse due to adrenal insufficiency of prematurity. Pediatr. Res. 2008; 63: 686-90.
Fernandez EF, Watterberg KL. Relative adrenal insufficiency in the preterm and term infant. J. Perinatol. 2009; 29 (Suppl 2): S44-9.
Shimokaze T, Akaba K, Saito E. Late-onset glucocorticoid-responsive circulatory collapse in preterm infants: Clinical characteristics of 14 patients. Tohoku. J. Exp. Med. 2015; 235: 241-8.
Bidegain M, Greenberg R, Simmons C, Dang C, Cotten CM, Smith PB. Vasopressin for refractory hypotension in extremely low birth weight infants. J. Pediatr. 2010; 157: 502-4.
Ikegami H, Funato M, Tamai H, Wada H, Nabetani M, Nishihara M. Low-dose vasopressin infusion therapy for refractory hypotension in ELBW infants. Pediatr. Int. 2010; 52: 368-73.
Kaga M, Matsuda T, Watanabe T et al. Renal vasodilatory action of arginine vasopressin in extremely low birth weight infants. Tohoku. J. Exp Med. 2013; 231: 159-64.
Koukoulas I, Risvanis J, Douglas-Denton R, Burrell LM, Moritz KM, Wintour EM. Vasopressin receptor expression in the placenta. Biol. Reprod. 2003; 69: 679-86.
Ostrowski NL, Young WS 3rd, Knepper MA, Lolait SJ. Expression of vasopressin V1a and V2 receptor messenger ribonucleic acid in the liver and kidney of embryonic, developing, and adult rats. Endocrinology 1993; 133: 1849-59.
Watanabe T, Matsuda T, Hanita T et al. Induction of necrotizing funisitis by fetal administration of intravenous granulocyte-colony stimulating factor and intra-amniotic endotoxin in premature fetal sheep. Pediatr. Res. 2007; 62: 670-3.
Saito M, Matsuda T, Okuyama K et al. Effect of intrauterine inflammation on fetal cerebral hemodynamics and white-matter injury in chronically instrumented fetal sheep. Am. J. Obstet. Gynecol. 2009; 200 (663): e1-11.
Kitanishi R, Matsuda T, Watanabe S et al. Cerebral ischemia or intrauterine inflammation promotes differentiation of oligodendroglial precursors in preterm ovine fetuses: Possible cellular basis for white matter injury. Tohoku. J. Exp. Med. 2014; 234: 299-307.
Kowallik P, Schulz R, Guth BD et al. Measurement of regional myocardial blood flow with multiple colored microspheres. Circulation 1991; 83: 974-82.
Miura Y, Matsuda T, Funakubo A et al. Novel modification of an artificial placenta: Pumpless arteriovenous extracorporeal life support in a premature lamb model. Pediatr. Res. 2012; 72: 490-4.
Zheng N, Zeng J, Ji QC et al. Improved liquid-liquid extraction with inter-well volume replacement dilution workflow and its application to quantify BMS-927711 in rat dried blood spots by UHPLC-MS/MS. J Pharm Biomed Anal. 2014; 89: 240-50.
Hanita T, Matsuda T, Saito M et al. Potential role of prenatal inflammation in the impairment of lung development following mechanical ventilation of preterm lambs. Reprod. Sci. 2017; 24: 478-87.
Daniel SS, Stark RI, Husain MK, Sanocka UM, James LS. Excretion of vasopressin in the hypoxic lamb: Comparison between fetus and newborn. Pediatr. Res. 1984; 18: 227-31.
Shinebourne EA, Vapaavuori EK, Williams RL, Heymann MA, Rudolph AM. Development of baroreflex activity in unanesthetized fetal and neonatal lambs. Circ. Res. 1972; 31: 710-8.
Holmes CL, Landry DW, Granton JT. Science review: Vasopressin and the cardiovascular system part 1 - receptor physiology. Crit. Care. 2003; 7: 427-34.