Defining murine monocyte differentiation into colonic and ileal macrophages.
colon
ileum
immunology
inflammation
intestine
macrophages
monocytes
mouse
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
08 01 2020
08 01 2020
Historique:
received:
07
07
2019
accepted:
27
11
2019
entrez:
10
1
2020
pubmed:
10
1
2020
medline:
27
8
2021
Statut:
epublish
Résumé
Monocytes are circulating short-lived macrophage precursors that are recruited on demand from the blood to sites of inflammation and challenge. In steady state, classical monocytes give rise to vasculature-resident cells that patrol the luminal side of the endothelium. In addition, classical monocytes feed macrophage compartments of selected organs, including barrier tissues, such as the skin and intestine, as well as the heart. Monocyte differentiation under conditions of inflammation has been studied in considerable detail. In contrast, monocyte differentiation under non-inflammatory conditions remains less well understood. Here we took advantage of a combination of cell ablation and precursor engraftment to investigate the generation of gut macrophages from monocytes. Collectively, we identify factors associated with the gradual adaptation of monocytes to tissue residency. Moreover, comparison of monocyte differentiation into the colon and ileum-resident macrophages revealed the graduated acquisition of gut segment-specific gene expression signatures.
Identifiants
pubmed: 31916932
doi: 10.7554/eLife.49998
pii: 49998
pmc: PMC6952180
doi:
pii:
Banques de données
GEO
['GSE140919']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Research Council
ID : 340345
Pays : International
Informations de copyright
© 2020, Gross-Vered et al.
Déclaration de conflit d'intérêts
MG, ST, AS, BB, CC, GS, TS, ED, SB, LC, DL, SJ No competing interests declared
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